Literature DB >> 30226442

The Effects of Metabolic Substrate Availability on Human Adipose-Derived Stem Cell Spheroid Survival.

Robert Coyle1, Jenny Yao2, Dylan Richards1, Ying Mei1,3.   

Abstract

IMPACT STATEMENT: Human adipose-derived stem cells (hADSCs) spheroids have displayed remarkable potential for treating ischemic injury. However, low nutrient (i.e., glucose and oxygen) availability in ischemic environments results in limited tissue viability posttransplantation. To develop an understanding of the effects of nutrient availability on spheroid survival, we utilized both in vitro and computational models to examine the limiting factors in metabolic supply for avascular microtissues, revealing the critical role of glucose to improve hADSC spheroid survival in ischemic conditions. These results may impact future strategies for improving hADSC transplantation efficacy through codelivery of metabolic substrates.

Entities:  

Keywords:  3D tissue culture; adipose-derived stem cell; ischemia; mathematical modeling; nutrient diffusion; spheroid

Mesh：

Year:  2018        PMID： 30226442      PMCID： PMC6482921          DOI： 10.1089/ten.TEA.2018.0163

Source DB:  PubMed          Journal:  Tissue Eng Part A        ISSN： 1937-3341            Impact factor:   3.845


  42 in total

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Authors:  Manuel Mazo; Juan José Gavira; Beatriz Pelacho; Felipe Prosper
Journal:  J Cardiovasc Transl Res       Date:  2010-11-30       Impact factor: 4.132

2.  Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissue.

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Review 3.  Adipose-derived stem cells for regenerative medicine.

Authors:  Jeffrey M Gimble; Adam J Katz; Bruce A Bunnell
Journal:  Circ Res       Date:  2007-05-11       Impact factor: 17.367

Review 4.  Challenges in cardiac tissue engineering.

Authors:  Gordana Vunjak-Novakovic; Nina Tandon; Amandine Godier; Robert Maidhof; Anna Marsano; Timothy P Martens; Milica Radisic
Journal:  Tissue Eng Part B Rev       Date:  2010-04       Impact factor: 6.389

5.  Stem cells: Cell therapy for cardiac repair: what is needed to move forward?

Authors:  Roberto Bolli; Shahab Ghafghazi
Journal:  Nat Rev Cardiol       Date:  2017-03-31       Impact factor: 32.419

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Authors:  Marc N Hirt; Arne Hansen; Thomas Eschenhagen
Journal:  Circ Res       Date:  2014-01-17       Impact factor: 17.367

7.  Angiogenesis in ischemic tissue produced by spheroid grafting of human adipose-derived stromal cells.

Authors:  Suk Ho Bhang; Seung-Woo Cho; Wan-Geun La; Tae-Jin Lee; Hee Seok Yang; Ah-Young Sun; Sang-Hong Baek; Jong-Won Rhie; Byung-Soo Kim
Journal:  Biomaterials       Date:  2011-01-22       Impact factor: 12.479

8.  In vivo adipose tissue regeneration by adipose-derived stromal cells isolated from GFP transgenic mice.

Authors:  Hiroshi Mizuno; Yurie Itoi; Satoko Kawahara; Rei Ogawa; Satoshi Akaishi; Hiko Hyakusoku
Journal:  Cells Tissues Organs       Date:  2007-11-02       Impact factor: 2.481

9.  Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts.

Authors:  Michael A Laflamme; Kent Y Chen; Anna V Naumova; Veronica Muskheli; James A Fugate; Sarah K Dupras; Hans Reinecke; Chunhui Xu; Mohammad Hassanipour; Shailaja Police; Chris O'Sullivan; Lila Collins; Yinhong Chen; Elina Minami; Edward A Gill; Shuichi Ueno; Chun Yuan; Joseph Gold; Charles E Murry
Journal:  Nat Biotechnol       Date:  2007-08-26       Impact factor: 54.908

Review 10.  Expert consensus document: Mitochondrial function as a therapeutic target in heart failure.

Authors:  David A Brown; Justin B Perry; Mitchell E Allen; Hani N Sabbah; Brian L Stauffer; Saame Raza Shaikh; John G F Cleland; Wilson S Colucci; Javed Butler; Adriaan A Voors; Stefan D Anker; Bertram Pitt; Burkert Pieske; Gerasimos Filippatos; Stephen J Greene; Mihai Gheorghiade
Journal:  Nat Rev Cardiol       Date:  2016-12-22       Impact factor: 32.419
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  4 in total

1.  Perspectives on scaling production of adipose tissue for food applications.

Authors:  John S K Yuen; Andrew J Stout; N Stephanie Kawecki; Sophia M Letcher; Sophia K Theodossiou; Julian M Cohen; Brigid M Barrick; Michael K Saad; Natalie R Rubio; Jaymie A Pietropinto; Hailey DiCindio; Sabrina W Zhang; Amy C Rowat; David L Kaplan
Journal:  Biomaterials       Date:  2021-11-29       Impact factor: 15.304

2.  Targeting HIF-α for robust prevascularization of human cardiac organoids.

Authors:  Robert C Coyle; Ryan W Barrs; Dylan J Richards; Emma P Ladd; Donald R Menick; Ying Mei
Journal:  J Tissue Eng Regen Med       Date:  2020-12-08       Impact factor: 3.963

Review 3.  Functional Properties of Human-Derived Mesenchymal Stem Cell Spheroids: A Meta-Analysis and Systematic Review.

Authors:  Sarah Ezquerra; Amparo Zuleta; Rodrigo Arancibia; José Estay; Francisco Aulestia; Flavio Carrion
Journal:  Stem Cells Int       Date:  2021-03-31       Impact factor: 5.443

4.  Enhanced cellular engraftment of adipose-derived mesenchymal stem cell spheroids by using nanosheets as scaffolds.

Authors:  Hisato Nagano; Yoshitaka Suematsu; Megumi Takuma; Shimpo Aoki; Ayano Satoh; Eiji Takayama; Manabu Kinoshita; Yuji Morimoto; Shinji Takeoka; Toshinori Fujie; Tomoharu Kiyosawa
Journal:  Sci Rep       Date:  2021-07-14       Impact factor: 4.379
  4 in total

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