Soniza Vieira Alves-Leon1, Monique da Rocha Lima2, Priscila Conrado Guerra Nunes2, Leila Maria Cardão Chimelli3, Kíssila Rabelo4, Rita Maria Ribeiro Nogueira5, Fernanda de Bruycker-Nogueira2, Elzinandes Leal de Azeredo2, Paulo Roberto Bahia6, Fernanda Cristina Rueda Lopes6, Jorge P Barreto Marcondes de Souza7, Fabrícia Lima Fontes-Dantas7, Marciano Viana Paes8, Elba Rs Lemos9, Flavia Barreto Santos2. 1. Centro de Referência e Pesquisa em Esclerose Múltipla e outras Doenças Desmielinizantes Inflamatórias Idiopáticas do SNC, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil/Programa de Pós Graduação em Neurologia da Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Rio de Janeiro, Brazil. 2. Laboratório de Imunologia Viral, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil. 3. Laboratório de Neuropatologia, Instituto Estadual do Cérebro Paulo Niemeyer, Rio de Janeiro, Brazil. 4. Laboratório de Ultraestrutura e Biologia Tecidual, Universidade do Estado do Rio de Janeiro (UNIRIO), Rio de Janeiro, Brazil. 5. Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil. 6. Centro de Referência e Pesquisa em Esclerose Múltipla e outras Doenças Desmielinizantes Inflamatórias Idiopáticas do SNC, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. 7. Programa de Pós Graduação em Neurologia da Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Rio de Janeiro, Brazil. 8. Laboratório Interdisciplinar de Pesquisas Médicas, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil. 9. Laboratório de Hantaviroses e Rickettsioses, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.
Abstract
BACKGROUND: A range of different neurological manifestations has been reported in fetuses and adults after Zika virus (ZIKV) infection. OBJECTIVE: We describe a detection of the ZIKV in the brain tissue from a multiple sclerosis (MS) patient with acute disseminated encephalomyelitis (ADEM)-like event in Rio de Janeiro, Brazil. METHODS: Biological samples collected during the hospitalization were tested by serology and molecular diagnostic for various infectious agents. Histopathological analysis was performed using the anti-flavivirus group 4G2 monoclonal antibody, anti-ZIKV non-structural 1 (NS1) monoclonal antibody, and anti-CD4, CD8, and CD11b antibodies. RESULTS: Anti-ZIKV IgM and IgG antibodies were positive in the serum and urine. A brain biopsy showed ZIKV protein in brain cells and T CD8 infiltration in brain tissue. CONCLUSION: Our data describe the coexistence of a recent central nervous system (CNS) ZIKV infection accompanied by a severe ADEM-like syndrome outcome in a patient with clinical history of MS. A de novo immune response concomitant with ZIKV infection might be involved in the mechanism of the ADEM-like syndrome and response to immunotherapy. The present report reinforces the importance of providing the differential diagnosis of acute episodes of MS exacerbation in an environment prone to ZIKV expression.
BACKGROUND: A range of different neurological manifestations has been reported in fetuses and adults after Zika virus (ZIKV) infection. OBJECTIVE: We describe a detection of the ZIKV in the brain tissue from a multiple sclerosis (MS) patient with acute disseminated encephalomyelitis (ADEM)-like event in Rio de Janeiro, Brazil. METHODS: Biological samples collected during the hospitalization were tested by serology and molecular diagnostic for various infectious agents. Histopathological analysis was performed using the anti-flavivirus group 4G2 monoclonal antibody, anti-ZIKV non-structural 1 (NS1) monoclonal antibody, and anti-CD4, CD8, and CD11b antibodies. RESULTS: Anti-ZIKV IgM and IgG antibodies were positive in the serum and urine. A brain biopsy showed ZIKV protein in brain cells and T CD8 infiltration in brain tissue. CONCLUSION: Our data describe the coexistence of a recent central nervous system (CNS) ZIKV infection accompanied by a severe ADEM-like syndrome outcome in a patient with clinical history of MS. A de novo immune response concomitant with ZIKV infection might be involved in the mechanism of the ADEM-like syndrome and response to immunotherapy. The present report reinforces the importance of providing the differential diagnosis of acute episodes of MS exacerbation in an environment prone to ZIKV expression.
Authors: Verena Schultz; Stephanie L Cumberworth; Quan Gu; Natasha Johnson; Claire L Donald; George A McCanney; Jennifer A Barrie; Ana Da Silva Filipe; Christopher Linington; Hugh J Willison; Julia M Edgar; Susan C Barnett; Alain Kohl Journal: Viruses Date: 2021-01-11 Impact factor: 5.048
Authors: Soniza Vieira Alves-Leon; Cristina Dos Santos Ferreira; Alice Laschuk Herlinger; Fabricia Lima Fontes-Dantas; Fernanda Cristina Rueda-Lopes; Ronaldo da Silva Francisco; João Paulo da Costa Gonçalves; Amanda Dutra de Araújo; Cláudia Cecília da Silva Rêgo; Luiza Mendonça Higa; Alexandra Lehmkuhl Gerber; Ana Paula de Campos Guimarães; Mariane Talon de Menezes; Marcelo Calado de Paula Tôrres; Richard Araújo Maia; Bruno Miceli Gonzalez Nogueira; Laise Carolina França; Marcos Martins da Silva; Christian Naurath; Aline Saraiva da Silva Correia; Claudia Cristina Ferreira Vasconcelos; Amilcar Tanuri; Orlando Costa Ferreira; Cynthia Chester Cardoso; Renato Santana Aguiar; Ana Tereza Ribeiro de Vasconcelos Journal: Front Genet Date: 2021-03-17 Impact factor: 4.599
Authors: Lavínia Schuler-Faccini; Miguel Del Campo; Alfredo García-Alix; Liana O Ventura; Juliano André Boquett; Vanessa van der Linden; André Pessoa; Hélio van der Linden Júnior; Camila V Ventura; Mariana Carvalho Leal; Thayne Woycinck Kowalski; Lais Rodrigues Gerzson; Carla Skilhan de Almeida; Lucélia Santi; Walter O Beys-da-Silva; André Quincozes-Santos; Jorge A Guimarães; Patricia P Garcez; Julia do Amaral Gomes; Fernanda Sales Luiz Vianna; André Anjos da Silva; Lucas Rosa Fraga; Maria Teresa Vieira Sanseverino; Alysson R Muotri; Rafael Lopes da Rosa; Alberto Mantovani Abeche; Clairton Marcolongo-Pereira; Diogo O Souza Journal: Front Genet Date: 2022-03-08 Impact factor: 4.599