Literature DB >> 30225831

Genetic Basis of Delayed Hypersensitivity Reactions to Drugs in Jewish and Arab Populations.

Mohammed Aboukaoud1, Shoshana Israel2, Chaim Brautbar2, Sara Eyal3.   

Abstract

Genetic variation can affect drug pharmacokinetics and pharmacodynamics and contribute to variability between individuals in response to medications. Specifically, differences in allele frequencies among individuals and ethnic groups have been associated with variation in their propensity to develop drug hypersensitivity reactions (HSRs). This article reviews the current knowledge on the genetic background of HSRs and its relevance to Jewish and Arab populations. The focus is on human leukocyte antigen (HLA) alleles and haplotypes as predictive markers of HSRs ("immunopharmacogenetics"), but other genes and alleles are described as well. Also discussed is the translation of the pharmacogenetic information to practice recommendations.

Entities:  

Keywords:  Arab; Jewish; human leukocyte antigens; hypersensitivity reactions

Mesh：

Substances：

Year:  2018        PMID： 30225831     DOI： 10.1007/s11095-018-2472-8

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  134 in total

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