Literature DB >> 30225789

Ketogenic Diets for Adult Neurological Disorders.

Tanya J W McDonald1, Mackenzie C Cervenka2.   

Abstract

The current review highlights the evidence supporting the use of ketogenic diet therapies in the management of a growing number of neurological disorders in adults. An overview of the scientific literature supporting posited mechanisms of therapeutic efficacy is presented including effects on neurotransmission, oxidative stress, and neuro-inflammation. The clinical evidence supporting ketogenic diet use in the management of adult epilepsy, malignant glioma, Alzheimer's disease, migraine headache, motor neuron disease, and other neurologic disorders is highlighted and reviewed. Lastly, common adverse effects of ketogenic therapy in adults, including gastrointestinal symptoms, weight loss, and transient dyslipidemia are discussed.

Entities:  

Keywords:  Alzheimer’s disease; Modified Atkins diet; epilepsy; malignant glioma; migraine headache.

Mesh：

Year:  2018        PMID： 30225789      PMCID： PMC6277302          DOI： 10.1007/s13311-018-0666-8

Source DB:  PubMed          Journal:  Neurotherapeutics        ISSN： 1878-7479            Impact factor:   7.620


  157 in total

Review 1.  Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials.

Authors:  Nassib Bezerra Bueno; Ingrid Sofia Vieira de Melo; Suzana Lima de Oliveira; Terezinha da Rocha Ataide
Journal:  Br J Nutr       Date:  2013-05-07       Impact factor: 3.718

2.  The ketogenic diet: seizure control correlates better with serum beta-hydroxybutyrate than with urine ketones.

Authors:  D L Gilbert; P L Pyzik; J M Freeman
Journal:  J Child Neurol       Date:  2000-12       Impact factor: 1.987

Review 3.  Ketogenic diet and other dietary treatments for epilepsy.

Authors:  Kirsty Martin; Cerian F Jackson; Robert G Levy; Paul N Cooper
Journal:  Cochrane Database Syst Rev       Date:  2016-02-09

Review 4.  The ketogenic diet: metabolic influences on brain excitability and epilepsy.

Authors:  Andrew Lutas; Gary Yellen
Journal:  Trends Neurosci       Date:  2012-12-08       Impact factor: 13.837

5.  Effect of a ketogenic meal on cognitive function in elderly adults: potential for cognitive enhancement.

Authors:  Miho Ota; Junko Matsuo; Ikki Ishida; Kotaro Hattori; Toshiya Teraishi; Hidekazu Tonouchi; Kinya Ashida; Takeshi Takahashi; Hiroshi Kunugi
Journal:  Psychopharmacology (Berl)       Date:  2016-08-27       Impact factor: 4.530

6.  Optimal clinical management of children receiving the ketogenic diet: recommendations of the International Ketogenic Diet Study Group.

Authors:  Eric H Kossoff; Beth A Zupec-Kania; Per E Amark; Karen R Ballaban-Gil; A G Christina Bergqvist; Robyn Blackford; Jeffrey R Buchhalter; Roberto H Caraballo; J Helen Cross; Maria G Dahlin; Elizabeth J Donner; Joerg Klepper; Rana S Jehle; Heung Dong Kim; Y M Christiana Liu; Judy Nation; Douglas R Nordli; Heidi H Pfeifer; Jong M Rho; Carl E Stafstrom; Elizabeth A Thiele; Zahava Turner; Elaine C Wirrell; James W Wheless; Pierangelo Veggiotti; Eileen P G Vining
Journal:  Epilepsia       Date:  2008-09-23       Impact factor: 5.864

7.  A pilot trial with modified Atkins' diet in adult patients with refractory epilepsy.

Authors:  Evelien Carrette; Kristl Vonck; Veerle de Herdt; Isabelle Dewaele; Robrecht Raedt; Lut Goossens; Michel Van Zandijcke; Wytse Wadman; Vijay Thadani; Paul Boon
Journal:  Clin Neurol Neurosurg       Date:  2008-06-24       Impact factor: 1.876

8.  Ketogenic diet protects dopaminergic neurons against 6-OHDA neurotoxicity via up-regulating glutathione in a rat model of Parkinson's disease.

Authors:  Baohua Cheng; Xinxin Yang; Liangxiang An; Bo Gao; Xia Liu; Shuwei Liu
Journal:  Brain Res       Date:  2009-06-25       Impact factor: 3.252

Review 9.  Tumor Metabolism, the Ketogenic Diet and β-Hydroxybutyrate: Novel Approaches to Adjuvant Brain Tumor Therapy.

Authors:  Eric C Woolf; Nelofer Syed; Adrienne C Scheck
Journal:  Front Mol Neurosci       Date:  2016-11-16       Impact factor: 5.639

10.  The effect of a ketogenic diet versus a high-carbohydrate, low-fat diet on sleep, cognition, thyroid function, and cardiovascular health independent of weight loss: study protocol for a randomized controlled trial.

Authors:  Stella Iacovides; Rebecca M Meiring
Journal:  Trials       Date:  2018-01-23       Impact factor: 2.279
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  19 in total

1.  Feasibility of a modified Atkins diet in glioma patients during radiation and its effect on radiation sensitization.

Authors:  C Woodhouse; T Ward; M Gaskill-Shipley; R Chaudhary
Journal:  Curr Oncol       Date:  2019-08-01       Impact factor: 3.677

2.  An Experimental Ketogenic Diet for Alzheimer Disease Was Nutritionally Dense and Rich in Vegetables and Avocado.

Authors:  Matthew K Taylor; Russell H Swerdlow; Jeffrey M Burns; Debra K Sullivan
Journal:  Curr Dev Nutr       Date:  2019-02-20

Review 3.  Ketogenic Diet in Alzheimer's Disease.

Authors:  Marta Rusek; Ryszard Pluta; Marzena Ułamek-Kozioł; Stanisław J Czuczwar
Journal:  Int J Mol Sci       Date:  2019-08-09       Impact factor: 5.923

4.  Gut Microbiotic Features Aiding the Diagnosis of Acute Ischemic Stroke.

Authors:  Lei Xiang; Yanfeng Lou; Lingyu Liu; Yuanling Liu; Weizheng Zhang; Jianxin Deng; Yubin Guan; Miaoqin She; Xinchao You; Minqi Liu; Hongwei Li; Xiaosong Xu; Fang Liu; Xiangsheng Cai
Journal:  Front Cell Infect Microbiol       Date:  2020-12-21       Impact factor: 5.293

5.  Glucose-Sparing Action of Ketones Boosts Functions Exclusive to Glucose in the Brain.

Authors:  Yuri Zilberter; Tanya Zilberter
Journal:  eNeuro       Date:  2020-11-09

6.  A Non-Invasive Determination of Ketosis-Induced Elimination of Chronic Daytime Somnolence in a Patient with Late-Stage Dementia (Assessed with Type 3 Diabetes): A Potential Role of Neurogenesis.

Authors:  Leslie A Lewis; Carl M Urban; Sami A Hashim
Journal:  J Alzheimers Dis Rep       Date:  2021-12-07

Review 7.  Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations.

Authors:  Huiyuan Zhu; Dexi Bi; Youhua Zhang; Cheng Kong; Jiahao Du; Xiawei Wu; Qing Wei; Huanlong Qin
Journal:  Signal Transduct Target Ther       Date:  2022-01-17

8.  Angiotensin (1-7) Expressing Probiotic as a Potential Treatment for Dementia.

Authors:  Abbi R Hernandez; Anisha Banerjee; Christy S Carter; Thomas W Buford
Journal:  Front Aging       Date:  2021-03-30

9.  KETOgenic diet therapy in patients with HEPatocellular adenoma: study protocol of a matched interventional cohort study.

Authors:  Christiaan Albert Johan Oudmaijer; Kirsten Anna Berk; Elisabeth Johanna Theresia Maria van der Louw; Rob de Man; Aart-Jan van der Lelij; Jan Hendrik Jozef Hoeijmakers; Jan IJzermans
Journal:  BMJ Open       Date:  2022-02-15       Impact factor: 2.692

10.  Feasibility and Biological Activity of a Ketogenic/Intermittent-Fasting Diet in Patients With Glioma.

Authors:  Karisa C Schreck; Fang-Chi Hsu; Adam Berrington; Bobbie Henry-Barron; Diane Vizthum; Lindsay Blair; Eric H Kossoff; Linda Easter; Christopher T Whitlow; Peter B Barker; Mackenzie C Cervenka; Jaishri O Blakeley; Roy E Strowd
Journal:  Neurology       Date:  2021-07-07       Impact factor: 11.800
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