Literature DB >> 30224525

Comparison of the Drug-Drug Interaction Potential of Daptomycin in Combination with Rifampin in Healthy Adult Volunteers.

Russell J Benefield1,2, E Susan Slechta3, Christopher M Gast4, Emily S Spivak5, Kimberly E Hanson3,5, Donald P Alexander6,2.   

Abstract

We evaluated the effects of rifampin coadministration and MDR1 single nucleotide polymorphisms on the disposition of daptomycin in twelve healthy adults. There were no significant changes from baseline in the clearance (0.53 versus 0.55 liters/h, P = 1.00), volume of distribution (7.0 versus 7.2 liter, P = 0.62), or half-life (9.7 versus 9.6 h, P = 0.89) of daptomycin after exposure to rifampin. The tested MDR1 polymorphisms were not associated with significant differences in daptomycin disposition.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  ABC transporters; MDR1; daptomycin; p-glycoprotein; pharmacogenetics; pharmacokinetics; rifampin

Mesh：

Substances：

Year:  2018        PMID： 30224525      PMCID： PMC6256791          DOI： 10.1128/AAC.01525-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

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Journal:  Circulation       Date:  2015-09-15       Impact factor: 29.690

Review 2.  Nuclear receptor PXR, transcriptional circuits and metabolic relevance.

Authors:  Chibueze A Ihunnah; Mengxi Jiang; Wen Xie
Journal:  Biochim Biophys Acta       Date:  2011-02-02

3.  Pharmacokinetics and tolerability of daptomycin at doses up to 12 milligrams per kilogram of body weight once daily in healthy volunteers.

Authors:  Mark Benvenuto; David P Benziger; Sara Yankelev; Gloria Vigliani
Journal:  Antimicrob Agents Chemother       Date:  2006-10       Impact factor: 5.191

4.  Impact of MDR1 haplotypes derived from C1236T, G2677T/A and C3435T on the pharmacokinetics of single-dose oral digoxin in healthy Chinese volunteers.

Authors:  Ping Xu; Zhi-Ping Jiang; Bi-Kui Zhang; Ji-Ying Tu; Huan-De Li
Journal:  Pharmacology       Date:  2008-09-23       Impact factor: 2.547

Review 5.  A synonymous polymorphism in a common MDR1 (ABCB1) haplotype shapes protein function.

Authors:  King Leung Fung; Michael M Gottesman
Journal:  Biochim Biophys Acta       Date:  2009-03-11

6.  Pharmacodynamic profile of daptomycin against Enterococcus species and methicillin-resistant Staphylococcus aureus in a murine thigh infection model.

Authors:  Prachi K Dandekar; Pamela R Tessier; Peter Williams; Charlie H Nightingale; David P Nicolau
Journal:  J Antimicrob Chemother       Date:  2003-08-13       Impact factor: 5.790

7.  Single-dose pharmacokinetics and antibacterial activity of daptomycin, a new lipopeptide antibiotic, in healthy volunteers.

Authors:  J R Woodworth; E H Nyhart; G L Brier; J D Wolny; H R Black
Journal:  Antimicrob Agents Chemother       Date:  1992-02       Impact factor: 5.191

8.  Influence of morbid obesity on the single-dose pharmacokinetics of daptomycin.

Authors:  Manjunath P Pai; Jeffrey P Norenberg; Tamara Anderson; Diane W Goade; Keith A Rodvold; Robert A Telepak; Renee-Claude Mercier
Journal:  Antimicrob Agents Chemother       Date:  2007-06-04       Impact factor: 5.191

9.  Comparison of the pharmacokinetics, safety and tolerability of daptomycin in healthy adult volunteers following intravenous administration by 30 min infusion or 2 min injection.

Authors:  Abhijit Chakraborty; Sandip Roy; Juergen Loeffler; Ricardo L Chaves
Journal:  J Antimicrob Chemother       Date:  2009-04-22       Impact factor: 5.790

Review 10.  Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor.

Authors:  Jiezhong Chen; Kenneth Raymond
Journal:  Ann Clin Microbiol Antimicrob       Date:  2006-02-15       Impact factor: 3.944
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  2 in total

1.  Daptomycin Physiology-Based Pharmacokinetic Modeling to Predict Drug Exposure and Pharmacodynamics in Skin and Bone Tissues.

Authors:  Romain Garreau; Damien Montange; Antoine Grillon; François Jehl; Tristan Ferry; Laurent Bourguignon; Sylvain Goutelle
Journal:  Clin Pharmacokinet       Date:  2022-08-16       Impact factor: 5.577

Review 2.  Clinical Pharmacokinetics of Daptomycin.

Authors:  Nicolas Gregoire; Alexia Chauzy; Julien Buyck; Blandine Rammaert; William Couet; Sandrine Marchand
Journal:  Clin Pharmacokinet       Date:  2020-12-14       Impact factor: 6.447
  2 in total

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