| Literature DB >> 3022429 |
L Lucchi, S Govoni, M Memo, C Missale, P F Spano, M Trabucchi.
Abstract
The effect of chronic lead treatment on pituitary dopamine (DA) D2 receptors was studied by measuring (-)sulpiride-displaceable [3H]spiroperidol-binding and DA-inhibited adenylate cyclase. Receptor number was reduced in lead-exposed animals and bromocriptine was less able to inhibit cyclase activity in pituitary homogenates. In addition, the capacity of DA to inhibit the VIP-stimulated cAMP formation was decreased.Entities:
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Year: 1986 PMID： 3022429 DOI： 10.1016/0378-4274(86)90116-5
Source DB: PubMed Journal: Toxicol Lett ISSN： 0378-4274 Impact factor: 4.372