Guillaume Baille1, Cécile Chenivesse2, Thierry Perez2, François Machuron3, Kathy Dujardin4, David Devos4, Luc Defebvre4, Caroline Moreau4. 1. Department of Neurology, Expert Center for Parkinson's Disease, INSERM UMRS_1171, Lille University Medical Center, LICEND COEN Center, Lille, F-59000 France. Electronic address: guillaume.baille@chru-lille.fr. 2. CHU Lille, Service de Pneumologie et Immuno-Allergologie, Centre de Compétence pour les Maladies Pulmonaires Rares, Univ. Lille, INSERM U1019, CIIL, Institut Pasteur de Lille, F-59000 Lille, France. 3. Univ. Lille, CHU Lille, EA 2694 - Santé Publique: Épidémiologie et Qualité des Soins, Department of Biostatistics, F-59000 Lille, France. 4. Department of Neurology, Expert Center for Parkinson's Disease, INSERM UMRS_1171, Lille University Medical Center, LICEND COEN Center, Lille, F-59000 France.
Abstract
INTRODUCTION: Dyspnea is one of the least well-characterized non-motor symptoms (NMS) associated with Parkinson's disease (PD). OBJECTIVE: To determine the frequency of dyspnea in a large, single-center cohort of consecutive PD patients with no history of lung or heart disease, and to compare clinical features in dyspneic vs. non-dyspneic patients. METHODS: Patients with abnormal cardiovascular and pulmonary results in a clinical examination were excluded. A positive response to at least one question ("In the last month, have you suffered from breathlessness?" and "In the last month, have you had trouble breathing normally?") was considered to signify the experience of dyspnea. MDS-UPDRS, global cognitive performance, non-motor symptoms and quality of life were assessed. RESULTS: In the cohort of 153 non-demented PD patients (mean age ± standard deviation: 63.9 ± 7.4; mean disease duration: 9.2 ± 6.1 years), the mean [95% confidence interval (CI)] frequency of dyspnea was 39.2% (31.5-47). After adjustment for disease severity, PD patients with dyspnea had a significantly higher Movement Disorders Society Unified Parkinson's Disease Rating Scale part I, II and IV scores, a higher HAD anxiety and depression scores and a significantly higher 8-item Parkinson's Disease Questionnaire. CONCLUSION: Dyspnea is a frequent NMS in PD. Its pathophysiology and prognostic value need more investigation.
INTRODUCTION:Dyspnea is one of the least well-characterized non-motor symptoms (NMS) associated with Parkinson's disease (PD). OBJECTIVE: To determine the frequency of dyspnea in a large, single-center cohort of consecutive PDpatients with no history of lung or heart disease, and to compare clinical features in dyspneic vs. non-dyspneicpatients. METHODS:Patients with abnormal cardiovascular and pulmonary results in a clinical examination were excluded. A positive response to at least one question ("In the last month, have you suffered from breathlessness?" and "In the last month, have you had trouble breathing normally?") was considered to signify the experience of dyspnea. MDS-UPDRS, global cognitive performance, non-motor symptoms and quality of life were assessed. RESULTS: In the cohort of 153 non-demented PDpatients (mean age ± standard deviation: 63.9 ± 7.4; mean disease duration: 9.2 ± 6.1 years), the mean [95% confidence interval (CI)] frequency of dyspnea was 39.2% (31.5-47). After adjustment for disease severity, PDpatients with dyspneahad a significantly higher Movement Disorders Society Unified Parkinson's Disease Rating Scale part I, II and IV scores, a higher HADanxiety and depression scores and a significantly higher 8-item Parkinson's Disease Questionnaire. CONCLUSION:Dyspnea is a frequent NMS in PD. Its pathophysiology and prognostic value need more investigation.
Authors: David Sulzer; Angelo Antonini; Valentina Leta; Anna Nordvig; Richard J Smeyne; James E Goldman; Osama Al-Dalahmah; Luigi Zecca; Alessandro Sette; Luigi Bubacco; Olimpia Meucci; Elena Moro; Ashley S Harms; Yaqian Xu; Stanley Fahn; K Ray Chaudhuri Journal: NPJ Parkinsons Dis Date: 2020-08-20
Authors: David Sulzer; Angelo Antonini; Valentina Leta; Anna Nordvig; Richard J Smeyne; James E Goldman; Osama Al-Dalahmah; Luigi Zecca; Alessandro Sette; Luigi Bubacco; Olimpia Meucci; Elena Moro; Ashley S Harms; Yaqian Xu; Stanley Fahn; K Ray Chaudhuri Journal: NPJ Parkinsons Dis Date: 2020-08-20