Jessica A Palakshappa1, John P Reilly2, William D Schweickert2, Brian J Anderson2, Viviane Khoury3, Michael G Shashaty4, David Fitzgerald2, Caitlin Forker2, Kelly Butler5, Caroline A Ittner2, Rui Feng6, D Clark Files7, Michael P Bonk2, Jason D Christie4, Nuala J Meyer2. 1. Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA; Section of Pulmonary, Critical Care, Allergy, and Immunologic Diseases, Wake Forest Baptist Health, Winston-Salem, NC 27157, USA. Electronic address: jpalaksh@wakehealth.edu. 2. Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA. 3. Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA. 4. Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, 19104, PA, USA. 5. Department of Occupational and Physical Therapy, Good Shepherd Penn Partners, Philadelphia, PA 19104, USA. 6. Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, 19104, PA, USA. 7. Section of Pulmonary, Critical Care, Allergy, and Immunologic Diseases, Wake Forest Baptist Health, Winston-Salem, NC 27157, USA.
Abstract
PURPOSE: The objective of this study is to describe the relationship between two quantitative muscle ultrasound measures, the rectus femoris cross-sectional area (RF-CSA) and quadriceps muscle thickness, with volitional measures of strength and function in critically ill patients with sepsis. MATERIALS AND METHODS: We performed a prospective study of patients admitted to a medical ICU with sepsis and shock or respiratory failure. We examined the association of two ultrasound measurements - the RF-CSA and quadriceps muscle thickness - with strength and function at day 7. Strength was determined using the Medical Research Council Score and function using Physical Function in the ICU Test, scored. RESULTS: Twenty-nine patients were enrolled; 19 patients had outcome testing performed. Over 7days, RF-CSA and thickness decreased by an average of 23.2% and 17.9%, respectively. The rate of change per day of RF-CSA displayed a moderate correlation with strength (ρ 0.51, p-value 0.03) on day 7. Baseline and day 7 RF-CSA did not show a significant correlation with either outcome. Quadriceps muscle thickness did not significantly correlate with either outcome. CONCLUSIONS: Muscle atrophy as detected by the rate of change in RF-CSA moderately correlated with strength one week after sepsis admission.
PURPOSE: The objective of this study is to describe the relationship between two quantitative muscle ultrasound measures, the rectus femoris cross-sectional area (RF-CSA) and quadriceps muscle thickness, with volitional measures of strength and function in critically illpatients with sepsis. MATERIALS AND METHODS: We performed a prospective study of patients admitted to a medical ICU with sepsis and shock or respiratory failure. We examined the association of two ultrasound measurements - the RF-CSA and quadriceps muscle thickness - with strength and function at day 7. Strength was determined using the Medical Research Council Score and function using Physical Function in the ICU Test, scored. RESULTS: Twenty-nine patients were enrolled; 19 patients had outcome testing performed. Over 7days, RF-CSA and thickness decreased by an average of 23.2% and 17.9%, respectively. The rate of change per day of RF-CSA displayed a moderate correlation with strength (ρ 0.51, p-value 0.03) on day 7. Baseline and day 7 RF-CSA did not show a significant correlation with either outcome. Quadriceps muscle thickness did not significantly correlate with either outcome. CONCLUSIONS:Muscle atrophy as detected by the rate of change in RF-CSA moderately correlated with strength one week after sepsis admission.
Authors: Sean M Bagshaw; H Thomas Stelfox; Jeffrey A Johnson; Robert C McDermid; Darryl B Rolfson; Ross T Tsuyuki; Quazi Ibrahim; Sumit R Majumdar Journal: Crit Care Med Date: 2015-05 Impact factor: 7.598
Authors: Wolfgang Gruther; Franz Kainberger; Veronika Fialka-Moser; Tatjana Paternostro-Sluga; Michael Quittan; Christian Spiss; Richard Crevenna Journal: J Rehabil Med Date: 2010-06 Impact factor: 2.912
Authors: Margaret S Herridge; Angela M Cheung; Catherine M Tansey; Andrea Matte-Martyn; Natalia Diaz-Granados; Fatma Al-Saidi; Andrew B Cooper; Cameron B Guest; C David Mazer; Sangeeta Mehta; Thomas E Stewart; Aiala Barr; Deborah Cook; Arthur S Slutsky Journal: N Engl J Med Date: 2003-02-20 Impact factor: 91.245
Authors: Jose Garnacho-Montero; Rosario Amaya-Villar; Jose Luis García-Garmendía; Juan Madrazo-Osuna; Carlos Ortiz-Leyba Journal: Crit Care Med Date: 2005-02 Impact factor: 7.598
Authors: S Nanas; K Kritikos; E Angelopoulos; A Siafaka; S Tsikriki; M Poriazi; D Kanaloupiti; M Kontogeorgi; M Pratikaki; D Zervakis; C Routsi; C Roussos Journal: Acta Neurol Scand Date: 2008-03-18 Impact factor: 3.209
Authors: M Eikermann; G Koch; M Gerwig; C Ochterbeck; M Beiderlinden; S Koeppen; M Neuhäuser; J Peters Journal: Intensive Care Med Date: 2006-01-27 Impact factor: 17.440
Authors: Zudin A Puthucheary; Angela S McNelly; Jai Rawal; Bronwen Connolly; Paul S Sidhu; Anthea Rowlerson; John Moxham; Stephen D Harridge; Nicholas Hart; Hugh E Montgomery Journal: Am J Respir Crit Care Med Date: 2017-01-01 Impact factor: 21.405
Authors: Gerald S Supinski; Emily N Valentine; Paul F Netzel; Elizabeth A Schroder; Lin Wang; Leigh Ann Callahan Journal: Crit Care Med Date: 2020-11 Impact factor: 9.296