Shoichi Sasaki1. 1. Department of Neurology, Agano City Hospital, Niigata, Japan. Electronic address: sasaki.shoichi@taupe.plala.or.jp.
Abstract
INTRODUCTION: The objective of this study was to examine the prevalence of the coexistence of parkinsonism in patients with mild cognitive impairment (MCI) or mild Alzheimer's disease (AD). METHODS: Outpatients were evaluated with Mini-Mental State Examination, Clinical Dementia Rating Scale, NIA-AA criteria, MRI, and 123I-IMP SPECT (3D-SSP). Parkinsonism in patients diagnosed with MCI (Mini-Mental State Examination ≥24, n = 63) or mild AD (Mini-Mental State Examination 20-23, n = 43) was examined using the Unified Parkinson's Disease Rating Scale-III and 123I-FP-CIT dopamine transporter SPECT. RESULTS: One hundred six patients (60-97 years) were enrolled. Fifty-six patients (52.8%) were diagnosed as having concomitant parkinsonism with rigidity and resting tremor and dopamine transporter reduction in the basal ganglia. The mean (SD) age (n = 56) was 80.6 (6.1) years, significantly older than patients without parkinsonism [77.6 (7.0) years, n = 50] (P < .05). The mean (SD) UPDRS-III score was 5.8 (2.4). CONCLUSION: The prevalence rate of the coexistence of mild parkinsonism in MCI or mild AD may be higher than previously recognized.
INTRODUCTION: The objective of this study was to examine the prevalence of the coexistence of parkinsonism in patients with mild cognitive impairment (MCI) or mild Alzheimer's disease (AD). METHODS: Outpatients were evaluated with Mini-Mental State Examination, Clinical Dementia Rating Scale, NIA-AA criteria, MRI, and 123I-IMP SPECT (3D-SSP). Parkinsonism in patients diagnosed with MCI (Mini-Mental State Examination ≥24, n = 63) or mild AD (Mini-Mental State Examination 20-23, n = 43) was examined using the Unified Parkinson's Disease Rating Scale-III and 123I-FP-CIT dopamine transporter SPECT. RESULTS: One hundred six patients (60-97 years) were enrolled. Fifty-six patients (52.8%) were diagnosed as having concomitant parkinsonism with rigidity and resting tremor and dopamine transporter reduction in the basal ganglia. The mean (SD) age (n = 56) was 80.6 (6.1) years, significantly older than patients without parkinsonism [77.6 (7.0) years, n = 50] (P < .05). The mean (SD) UPDRS-III score was 5.8 (2.4). CONCLUSION: The prevalence rate of the coexistence of mild parkinsonism in MCI or mild AD may be higher than previously recognized.
Authors: Zhuang Wu; Hang Xu; Sha Zhu; Ruxin Gu; Min Zhong; Xu Jiang; Bo Shen; Jun Zhu; Yang Pan; Jingde Dong; Jun Yan; Wenbin Zhang; Li Zhang Journal: Risk Manag Healthc Policy Date: 2021-03-15
Authors: Yesica Gloria; Kelly Ceyzériat; Stergios Tsartsalis; Philippe Millet; Benjamin B Tournier Journal: Sci Rep Date: 2021-09-30 Impact factor: 4.379