Kyungtae Ko1, Won Ki Lee2, Cheol Young Oh3, Seong Ho Lee4, Sung Tae Cho5, Woo Jin Bang3, Tae Young Shin2, Min Soo Choo2, Jin Seon Cho4, Young Goo Lee3, Dae Yul Yang6. 1. Department of Urology, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea. palindromes@hanmail.net. 2. Department of Urology, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon, Korea. 3. Department of Urology, Hallym University Hallym Sacred Heart Hospital, Gyeonggi, Korea. 4. Department of Urology, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea. 5. Department of Urology, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea. 6. Department of Urology, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea.
Abstract
Purpose: To compare the efficacy of non-steroidal anti-inflammatory drugs (NSAIDs) combination therapy to single-agent antibiotic therapy for the resolution of symptoms during two restricted activity days in patients with acute uncomplicated cystitis (AUC)Materials and Methods: We performed a prospective, randomized control pilot study. A total of 55 patients were enrolled. Group I (n=28) was treated with cepodoxime (100 mg twice per day), and Group II (n=27) was treated with cepodoxime (100 mg) and aceclofenac (100 mg) twice per day; both groups were treated for three days. Upon dysuria after each administration, the participants entered a value on a numerical pain scale. The primary outcome was whether there were any differences in the decrease rate in pain scale between the two groups.Result: The average age of the 55 patients was 49.9 ± 13.5 years, and prior to the clinical visit, the patients ex-perienced an average of 2.4 ± 2.2 days of dysuria symptoms. The average numerical pain scale score for dysuria was 4.98 ± 2.18. Thirty-four patients (61.8%) showed positive culture results, and E. coli was the most commonly found bacteria, cultured in 32 patients.Fifty-one patients visited the clinic on day 7, and 42 (76.4%) reported symptom improvement, while nine patients (16.3%) had persistent symptoms. The follow-up numerical pain score was 0.39 ± 1.02 points. The pain score was dramatically decreased after medication. No difference was observed in the magnitude of the pain scale reduction between the two groups (P = 0.134). However, group II showed faster symptom resolution (P = 0.035) at the third administration (day 1.5). Conclusion: Combination therapy with NSAIDs and antibiotics for AUC patients can improve symptoms faster during two restricted activity days when patients have difficulty performing daily living activities.
RCT Entities:
Purpose: To compare the efficacy of non-steroidal anti-inflammatory drugs (NSAIDs) combination therapy to single-agent antibiotic therapy for the resolution of symptoms during two restricted activity days in patients with acute uncomplicated cystitis (AUC)Materials and Methods: We performed a prospective, randomized control pilot study. A total of 55 patients were enrolled. Group I (n=28) was treated with cepodoxime (100 mg twice per day), and Group II (n=27) was treated with cepodoxime (100 mg) and aceclofenac (100 mg) twice per day; both groups were treated for three days. Upon dysuria after each administration, the participants entered a value on a numerical pain scale. The primary outcome was whether there were any differences in the decrease rate in pain scale between the two groups.Result: The average age of the 55 patients was 49.9 ± 13.5 years, and prior to the clinical visit, the patients ex-perienced an average of 2.4 ± 2.2 days of dysuria symptoms. The average numerical pain scale score for dysuria was 4.98 ± 2.18. Thirty-four patients (61.8%) showed positive culture results, and E. coli was the most commonly found bacteria, cultured in 32 patients.Fifty-one patients visited the clinic on day 7, and 42 (76.4%) reported symptom improvement, while nine patients (16.3%) had persistent symptoms. The follow-up numerical pain score was 0.39 ± 1.02 points. The pain score was dramatically decreased after medication. No difference was observed in the magnitude of the pain scale reduction between the two groups (P = 0.134). However, group II showed faster symptom resolution (P = 0.035) at the third administration (day 1.5). Conclusion: Combination therapy with NSAIDs and antibiotics for AUC patients can improve symptoms faster during two restricted activity days when patients have difficulty performing daily living activities.
Authors: Sandesh Gautam; Rajeev Shrestha; Mohammad R Ghani; Mahmoud M Ali; Manish Kc; Yomna A Elfert; Vanessa Chong; Bayode Romeo Adegbite Journal: SAGE Open Med Date: 2022-09-04
Authors: Albert Macaire C Ong Lopez; Charles Jeffrey L Tan; Antonio S Yabon; Armin N Masbang Journal: BMC Infect Dis Date: 2021-06-29 Impact factor: 3.090