Lewis acid-catalyzed Friedel-Crafts reactions toward highly versatile, α-quaternary oxime ethers.

The synthesis of all-carbon-substituted, quaternary stereocenters through Lewis acid-catalyzed Friedel-Crafts alkylation of cyclic and acyclic 2-hydroxy oxime ethers proceeds under mild reaction conditions and with high yields. Moreover, the oxime ether moiety can be easily manipulated into various functional groups through subsequent modifications.