Literature DB >> 3022030

Changes in cell characteristics due to culture conditions in cell lines from human small cell lung cancer.

T Terasaki, Y Shimosato, T Nakajima, M Tsumuraya, S Morinaga, S Hirohashi, K Yamaguchi, K Kato, H Ichinose, T Nagatsu.   

Abstract

Eight cultured cell lines were established from human small cell lung cancers. Every cell line showed the morphological and biochemical characteristics of small cell cancer. Changes in cell characteristics were observed in many of these cell lines when culture conditions were changed: "oat cell type" changed to "intermediate cell type" and vice versa when serum-free medium was changed to serum-supplemented medium; a deficiency of vitamin A in the medium caused a change to squamous cells and vice versa; and a tumor promoter (teleocidin B) enhanced the adherence of these cells to the surface of plastic culture dishes. These findings provide evidence that many small cell lung cancer cell lines can change their morphology with changes in the environment of the cells.

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Year:  1986        PMID： 3022030

Source DB:  PubMed          Journal:  Jpn J Clin Oncol        ISSN： 0368-2811            Impact factor:   3.019


  15 in total

1.  A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers.

Authors:  Sana Yokoi; Kohichiroh Yasui; Fumiko Saito-Ohara; Katsumi Koshikawa; Toshihiko Iizasa; Takehiko Fujisawa; Takeo Terasaki; Akira Horii; Takashi Takahashi; Setsuo Hirohashi; Johji Inazawa
Journal:  Am J Pathol       Date:  2002-07       Impact factor: 4.307

2.  Mutation and expression of the DCC gene in human lung cancer.

Authors:  T Kohno; T Sato; S Takakura; K Takei; K Inoue; M Nishioka; J Yokota
Journal:  Neoplasia       Date:  2000 Jul-Aug       Impact factor: 5.715

3.  K-sam, an amplified gene in stomach cancer, is a member of the heparin-binding growth factor receptor genes.

Authors:  Y Hattori; H Odagiri; H Nakatani; K Miyagawa; K Naito; H Sakamoto; O Katoh; T Yoshida; T Sugimura; M Terada
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

4.  Production of transforming growth factor-alpha in human tumour cell lines.

Authors:  K Imanishi; K Yamaguchi; M Suzuki; S Honda; N Yanaihara; K Abe
Journal:  Br J Cancer       Date:  1989-05       Impact factor: 7.640

5.  Enhancement of sensitivity of human lung adenocarcinoma cells to growth-inhibitory activity of interferon alpha by differentiation-inducing agents.

Authors:  I Goto; Y Yamamoto-Yamaguchi; Y Honma
Journal:  Br J Cancer       Date:  1996-08       Impact factor: 7.640

6.  Integrin expression and ability to adhere to extracellular matrix proteins and endothelial cells in human lung cancer lines.

Authors:  M Hirasawa; N Shijubo; T Uede; S Abe
Journal:  Br J Cancer       Date:  1994-09       Impact factor: 7.640

7.  A distinct role for interleukin-6 as a major mediator of cellular adjustment to an altered culture condition.

Authors:  Hwa-Kyung Son; Iha Park; Jue Young Kim; Do Kyeong Kim; Rasika P Illeperuma; Jung Yoon Bae; Doo Young Lee; Eun-Sang Oh; Da-Woon Jung; Darren R Williams; Jin Kim
Journal:  J Cell Biochem       Date:  2015-11       Impact factor: 4.429

8.  Quantitative distribution of cluster 1 small cell lung cancer antigen in cancerous and non-cancerous tissues, cultured cells and sera.

Authors:  T Hirano; S Hirohashi; T Kunii; M Noguchi; Y Shimosato; Y Hayata
Journal:  Jpn J Cancer Res       Date:  1989-04

9.  Development and elongation of neurite-like outgrowth on small cell lung cancer cell lines.

Authors:  K Tanaka; T Terasaki
Journal:  Jpn J Cancer Res       Date:  1997-02

10.  Pulmonary large cell carcinoma expressing neuroendocrine markers: the morphological, biological, and neuroendocrine features of their cell lines and surgical cases.

Authors:  K Kasai; T Kameya; Y Kawakubo; Y Sato; C Wada; H Itoh
Journal:  Jpn J Cancer Res       Date:  1992-09
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