Yeli Wang1, Jingwen Zhu2, Aase Handberg3, Kim Overvad4, Anne Tjønneland5, Eric B Rimm6, Majken K Jensen7. 1. Health Services and Systems Research, Duke-NUS Medical School, 169857, Singapore. 2. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA. 3. Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, 9100, Denmark; Department of Clinical Medicine, Faculty of Medicine, Aalborg University, Aalborg, 9100, Denmark. 4. Department of Cardiology, Aalborg University Hospital, Aalborg, 9100, Denmark; Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, 8000, Denmark. 5. Danish Cancer Society Research Center, Copenhagen, 2100, Denmark. 6. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. 7. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. Electronic address: mkjensen@hsph.harvard.edu.
Abstract
BACKGROUND AND AIMS: CD36 is a cholesterol receptor involved in the uptake of oxidized low-density lipoprotein cholesterol and development of atherosclerotic plaques. Cross-sectional studies have shown correlations between plasma CD36 and atherosclerosis but no prospective study has examined the association yet. We prospectively examined the association between plasma CD36 levels and risk of incident coronary heart disease (CHD) in a Danish population. METHODS: Plasma CD36 levels were measured in a case-cohort study nested within the Danish population-based cohort, the Diet, Cancer and Health Study. A total of 1963 incident CHD events occurred between baseline (1993-1997) and 2008, and a sub-cohort of 1759 participants were randomly selected as reference. Cox proportional hazard regression models were used to compute the hazard ratio (HR) and corresponding 95% confidence interval (CI). RESULTS: After adjusting for CHD risk factors, including history of hypercholesterolemia and diabetes, elevated plasma CD36 levels were not associated with higher CHD risk in the total population, and the HR comparing the highest versus lowest tertile of CD36 levels was 1.02 (95% CI: 0.84-1.23). High CD36 levels were only found to be associated with risk of CHD in combination with prevalent diabetes (HR = 2.83, 95% CI: 1.08-7.45) vs. the joint reference group of lowest CD36 tertile and no diabetes. CONCLUSIONS: Plasma CD36 levels were not predictive of CHD risk in the general population.
BACKGROUND AND AIMS: CD36 is a cholesterol receptor involved in the uptake of oxidized low-density lipoprotein cholesterol and development of atherosclerotic plaques. Cross-sectional studies have shown correlations between plasma CD36 and atherosclerosis but no prospective study has examined the association yet. We prospectively examined the association between plasma CD36 levels and risk of incident coronary heart disease (CHD) in a Danish population. METHODS: Plasma CD36 levels were measured in a case-cohort study nested within the Danish population-based cohort, the Diet, Cancer and Health Study. A total of 1963 incident CHD events occurred between baseline (1993-1997) and 2008, and a sub-cohort of 1759 participants were randomly selected as reference. Cox proportional hazard regression models were used to compute the hazard ratio (HR) and corresponding 95% confidence interval (CI). RESULTS: After adjusting for CHD risk factors, including history of hypercholesterolemia and diabetes, elevated plasma CD36 levels were not associated with higher CHD risk in the total population, and the HR comparing the highest versus lowest tertile of CD36 levels was 1.02 (95% CI: 0.84-1.23). High CD36 levels were only found to be associated with risk of CHD in combination with prevalent diabetes (HR = 2.83, 95% CI: 1.08-7.45) vs. the joint reference group of lowest CD36 tertile and no diabetes. CONCLUSIONS: Plasma CD36 levels were not predictive of CHD risk in the general population.
Authors: Dina Mukushkina; Dana Aisina; Anna Pyrkova; Alma Ryskulova; Siegfried Labeit; Anatoliy Ivashchenko Journal: Front Genet Date: 2020-11-04 Impact factor: 4.599
Authors: Gary A Cuthbert; Faheem Shaik; Michael A Harrison; Sreenivasan Ponnambalam; Shervanthi Homer-Vanniasinkam Journal: Cells Date: 2020-11-10 Impact factor: 6.600