Literature DB >> 30218707

Th17 and Treg lymphocytes in obesity and Type 2 diabetic patients.

Mei Wang1, Fuqiong Chen1, Jingli Wang2, Zhixuan Zeng1, Qin Yang3, Shiying Shao4.   

Abstract

Assumption that the pathogenesis of obesity-associated type 2 diabetes (T2DM) encompasses inflammation and autoimmune aspects is increasingly recognized. In the state of obesity and T2DM, the imbalance of T helper 17 (Th17) cells and regulatory T (Treg) cells are observed. These alterations reflect a loss of T cell homeostasis, which may contribute to tissue and systemic inflammation and immunity in T2DM. In this review we will discuss the accumulating data supporting the concept that Th17/Treg mediated immune responses are present in obesity-related T2DM pathogenesis, and provide evidences that restoration of Th17/Treg imbalance may be a possible therapeutic avenue for the prevention and treatment of T2DM and its complications.
Copyright © 2018. Published by Elsevier Inc.

Entities:  

Keywords:  Obesity; Th17 cell; Treg cell; Type 2 diabetes

Mesh：

Year:  2018        PMID： 30218707     DOI： 10.1016/j.clim.2018.09.005

Source DB:  PubMed          Journal:  Clin Immunol        ISSN： 1521-6616            Impact factor:   3.969


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