Marco Mascitti1, Corrado Rubini2, Francesco De Michele2, Paolo Balercia3, Riccardo Girotto3, Giuseppe Troiano4, Lorenzo Lo Muzio4, Andrea Santarelli5. 1. Department of Clinical Specialistic and Dental Sciences, Marche Polytechnic University, Ancona, Italy. Electronic address: marcomascitti86@hotmail.it. 2. Department of Biomedical Sciences and Public Health, Marche Polytechnic University, Ancona, Italy. 3. Department of Oral and Head-Neck Surgery, Umberto I General Hospital, Marche Polytechnic University, Ancona, Italy. 4. Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy. 5. Department of Clinical Specialistic and Dental Sciences, Marche Polytechnic University, Ancona, Italy; Dentistry Clinic, National Institute of Health and Science of Aging, INRCA, Ancona, Italy.
Abstract
OBJECTIVE: In this study, we evaluated the 8th edition of American Joint Committee on Cancer (AJCC) staging criteria and lymph node ratio (LNR) to identify patients affected by squamous cell carcinoma of the tongue (SCCT) with a poor prognosis. STUDY DESIGN: Seventy-three cases of SCCT were analyzed retrospectively. Tumor staging was revised according to the 7th and 8th editions of the AJCC criteria. Depth of invasion (DOI), extranodal extension (ENE), and LNR were evaluated. RESULTS: Twenty-five cases were reclassified: 17 patients received an upstage in the staging score, and in 8 cases in the same stage group, pT or pN was changed. In the pT-upstaged group, 7 patients experienced recurrence, and 8 died. In the pN-upstaged group, 9 patients developed recurrence, and 10 died. The number of disease recurrence or death was higher in the groups of patients who received an upstage in pN and in the staging score (P < .05). The pN-upstaged group showed worse disease-free survival (DFS) and overall survival (OS) (P < .05). LNR was higher in patients with recurrence, and among these, LNR was lower in patients with ENE (P <.05). CONCLUSIONS: The 8th edition of the AJCC criteria allows for better stratification of patients with SCCT. The implementation of ENE and LNR to pN classification seems to identify patients with worse DFS and OS.
OBJECTIVE: In this study, we evaluated the 8th edition of American Joint Committee on Cancer (AJCC) staging criteria and lymph node ratio (LNR) to identify patients affected by squamous cell carcinoma of the tongue (SCCT) with a poor prognosis. STUDY DESIGN: Seventy-three cases of SCCT were analyzed retrospectively. Tumor staging was revised according to the 7th and 8th editions of the AJCC criteria. Depth of invasion (DOI), extranodal extension (ENE), and LNR were evaluated. RESULTS: Twenty-five cases were reclassified: 17 patients received an upstage in the staging score, and in 8 cases in the same stage group, pT or pN was changed. In the pT-upstaged group, 7 patients experienced recurrence, and 8 died. In the pN-upstaged group, 9 patients developed recurrence, and 10 died. The number of disease recurrence or death was higher in the groups of patients who received an upstage in pN and in the staging score (P < .05). The pN-upstaged group showed worse disease-free survival (DFS) and overall survival (OS) (P < .05). LNR was higher in patients with recurrence, and among these, LNR was lower in patients with ENE (P <.05). CONCLUSIONS: The 8th edition of the AJCC criteria allows for better stratification of patients with SCCT. The implementation of ENE and LNR to pN classification seems to identify patients with worse DFS and OS.
Authors: Johannes Laimer; Anke Lauinger; Otto Steinmassl; Vincent Offermanns; Astrid E Grams; Bettina Zelger; Emanuel Bruckmoser Journal: Diagnostics (Basel) Date: 2020-04-02
Authors: Marco Mascitti; Lucrezia Togni; Corrado Rubini; Giuseppe Troiano; Lorenzo Lo Muzio; Andrea Santarelli Journal: Histol Histopathol Date: 2020-09-28 Impact factor: 2.303
Authors: Flora Yan; Hannah M Knochelmann; Patrick F Morgan; John M Kaczmar; David M Neskey; Evan M Graboyes; Shaun A Nguyen; Besim Ogretmen; Anand K Sharma; Terry A Day Journal: Cancers (Basel) Date: 2020-06-11 Impact factor: 6.639