Vincenzo Abbate1, Giovanni Dell'Aversana Orabona2, Giovanni Salzano2, Paola Bonavolontà2, Fabio Maglitto2, Antonio Romano2, Filippo Tarabbia2, Mario Turri-Zanoni3, Federica Attanasi4, Alessandro Espedito Di Lauro5, Giorgio Iaconetta6, Luigi Califano2. 1. Maxillofacial Surgery Unit, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II, Via Pansini 5, 80100, Naples, Italy. Electronic address: vincenzo.abbate@unina.it. 2. Maxillofacial Surgery Unit, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II, Via Pansini 5, 80100, Naples, Italy. 3. Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, Ospedale di Circolo e Fondazione Macchi, Varese, Italy. 4. Department of Statistical Sciences, University La Sapienza, Piazzale Aldo Moro 5, 00185, Rome, Italy. 5. Neurosurgery Unit Department of Medicine, Surgery and Odontoiatrics, University of Salerno, Via Giovanni Paolo II 132, 84084, Fisciano, Salerno, Italy. 6. Division of Dentistry, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II, Via Pansini 5, 80100, Naples, Italy.
Abstract
BACKGROUND: Optimum management of clinically negative neck (cN0) remains controversial in early stage (T1-T2) squamous cell cancer of the oral tongue (OTSCC). The purpose of this study was to investigate the value of pre-treatment Neutrophil-to lymphocyte ratio (NLR) in predicting occult cervical metastasis in stage I and II OTSCC. METHODS: We carried out a retrospective chart review on 110 patients suffering from early stage OTSCC who were surgically treated with tumour excision and elective neck dissection (END). Our cohort was divided in pN+ and pN0 groups basing on histopathological examination after elective neck dissection. For each patient pre-treatment NLR was calculated. RESULTS: A statistically significant relationship between high levels of pre-treatment NLR and probability rate for neck occult metastases (0.000496 p-value) has been found. On our model the cut-off value was set for NLR >2.93. Above this level the probability to finding metastasis in a clinically negative neck increases exponentially. CONCLUSION: These preliminary results offer clinicians an easily obtainable tool to stratify patients based on risks of metastatic node in whom END could be indicated.
BACKGROUND: Optimum management of clinically negative neck (cN0) remains controversial in early stage (T1-T2) squamous cell cancer of the oral tongue (OTSCC). The purpose of this study was to investigate the value of pre-treatment Neutrophil-to lymphocyte ratio (NLR) in predicting occult cervical metastasis in stage I and II OTSCC. METHODS: We carried out a retrospective chart review on 110 patients suffering from early stage OTSCC who were surgically treated with tumour excision and elective neck dissection (END). Our cohort was divided in pN+ and pN0 groups basing on histopathological examination after elective neck dissection. For each patient pre-treatment NLR was calculated. RESULTS: A statistically significant relationship between high levels of pre-treatment NLR and probability rate for neck occult metastases (0.000496 p-value) has been found. On our model the cut-off value was set for NLR >2.93. Above this level the probability to finding metastasis in a clinically negative neck increases exponentially. CONCLUSION: These preliminary results offer clinicians an easily obtainable tool to stratify patients based on risks of metastatic node in whom END could be indicated.
Authors: Mustafa Çolak; Fakih Cihat Eravcı; Süleyman Emre Karakurt; Mehmet Fatih Karakuş; Aykut İkincioğulları; Kürşat Murat Özcan Journal: Indian J Otolaryngol Head Neck Surg Date: 2019-06-05
Authors: Tara E Henn; Ashley N Anderson; Yvette R Hollett; Thomas L Sutton; Brett S Walker; John R Swain; David A Sauer; Daniel R Clayburgh; Melissa H Wong Journal: Head Neck Date: 2021-04-09 Impact factor: 3.821
Authors: Pierluigi Mariani; Diana Russo; Marco Maisto; Giuseppe Troiano; Vito Carlo Alberto Caponio; Marco Annunziata; Luigi Laino Journal: J Oral Pathol Med Date: 2021-12-09 Impact factor: 3.539
Authors: Filippo Marchi; Francesco Missale; Fabiola Incandela; Marta Filauro; Francesco Mazzola; Francesco Mora; Alberto Paderno; Giampiero Parrinello; Cesare Piazza; Giorgio Peretti Journal: Laryngoscope Investig Otolaryngol Date: 2019-08-28