Literature DB >> 3021670

Synthesis and purification of 2-deoxy-2-[18F]fluoro-D-glucose and 2-deoxy-2-[18F]fluoro-D-mannose: characterization of products by 1H- and 19F-NMR spectroscopy.

F Oberdorfer, W E Hull, B C Traving, W Maier-Borst.   

Abstract

A procedure has been developed that allows the separation of 2-deoxy-2-[18F]fluoro-D-glucose from 2-deoxy-2-[18F]fluoro-D-mannose employing selectively optimized ion-moderated partition chromatography. Both compounds can be obtained with a greater than 98% chemical and radiochemical purity in about one half-life of 18F. Both the alpha- and beta-anomers of both sugars were completely characterized by high-resolution 1H- and 19F-NMR spectroscopy. Various convenient preparation methods for 2-deoxy-2-[18F]fluoro-D-glucose were compared.

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Year:  1986        PMID： 3021670     DOI： 10.1016/0883-2889(86)90263-7

Source DB:  PubMed          Journal:  Int J Rad Appl Instrum A        ISSN： 0883-2889


  4 in total

1.  PET imaging of ischemia-induced impairment of mitochondrial complex I function in monkey brain.

Authors:  Hideo Tsukada; Hiroyuki Ohba; Shingo Nishiyama; Masakatsu Kanazawa; Takeharu Kakiuchi; Norihiro Harada
Journal:  J Cereb Blood Flow Metab       Date:  2014-01-22       Impact factor: 6.200

2.  Imaging mitochondrial complex I activation during a vibrotactile stimulation: A PET study using [18F]BCPP-EF in the conscious monkey brain.

Authors:  Jingwan Fang; Hiroyuki Ohba; Fumio Hashimoto; Hideo Tsukada; Feiyan Chen; Huafeng Liu
Journal:  J Cereb Blood Flow Metab       Date:  2020-01-16       Impact factor: 6.200

3.  Histamine regulation in glucose and lipid metabolism via histamine receptors: model for nonalcoholic steatohepatitis in mice.

Authors:  Ke-Yong Wang; Akihide Tanimoto; Sohsuke Yamada; Xin Guo; Yan Ding; Teruo Watanabe; Takeshi Watanabe; Kimitoshi Kohno; Ken-Ichi Hirano; Hideo Tsukada; Yasuyuki Sasaguri
Journal:  Am J Pathol       Date:  2010-06-21       Impact factor: 4.307

4.  Comparing amyloid-β deposition, neuroinflammation, glucose metabolism, and mitochondrial complex I activity in brain: a PET study in aged monkeys.

Authors:  Hideo Tsukada; Shingo Nishiyama; Hiroyuki Ohba; Masakatsu Kanazawa; Takeharu Kakiuchi; Norihiro Harada
Journal:  Eur J Nucl Med Mol Imaging       Date:  2014-06-12       Impact factor: 9.236
  4 in total

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