Literature DB >> 3021635

Lymphoblastoid cell lines and Burkitt-lymphoma-derived cell lines differ in the expression of a second Epstein-Barr virus encoded nuclear antigen.

I Ernberg, B Kallin, J Dillner, K Falk, B Ehlin-Henriksson, M L Hammarskjöld, G Klein.   

Abstract

Twenty-seven Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines and 27 EBV-carrying Burkitt-lymphoma-derived lines were analyzed for expression of the second EBV-encoded nuclear antigen (EBNA-2) by immunoblotting and anticomplement immunofluorescence with EBNA-2-specific sera. While all lymphoblastoid cell lines expressed EBNA-2, only 10 of the 27 BL lines were EBNA-2-positive. Comparison of the EBNA-2 coding BamHI W-, Y- and H-fragments of EBV-DNA in the different cell lines by restriction enzyme analysis suggests that EBNA-2 negativity is due either to sequence diversity or to a deletion in the BamHI WYH region.

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Year:  1986        PMID： 3021635     DOI： 10.1002/ijc.2910380517

Source DB:  PubMed          Journal:  Int J Cancer        ISSN： 0020-7136            Impact factor:   7.396


  11 in total

1.  Monoclonal and polyclonal antibodies against Epstein-Barr virus nuclear antigen 5 (EBNA-5) detect multiple protein species in Burkitt's lymphoma and lymphoblastoid cell lines.

Authors:  J Finke; M Rowe; B Kallin; I Ernberg; A Rosén; J Dillner; G Klein
Journal:  J Virol       Date:  1987-12       Impact factor: 5.103

2.  The Epstein-Barr virus BNLF-1 membrane protein LMP1 induces homotypic adhesion mediated by CD11a/CD18 in a murine B-cell line, mimicking the action of phorbol ester.

Authors:  R Salcedo; S M Fuerstenberg; M Patarroyo; G Winberg
Journal:  J Virol       Date:  1991-10       Impact factor: 5.103

3.  Reaction of antibodies to rheumatoid arthritis nuclear antigen with a synthetic peptide corresponding to part of Epstein-Barr nuclear antigen 1.

Authors:  P J Venables; T Pawlowski; P A Mumford; C Brown; D H Crawford; R N Maini
Journal:  Ann Rheum Dis       Date:  1988-04       Impact factor: 19.103

Review 4.  Epstein-Barr virus infection and autoimmunity in rheumatoid arthritis.

Authors:  P Venables
Journal:  Ann Rheum Dis       Date:  1988-04       Impact factor: 19.103

5.  5-Azacytidine up regulates the expression of Epstein-Barr virus nuclear antigen 2 (EBNA-2) through EBNA-6 and latent membrane protein in the Burkitt's lymphoma line rael.

Authors:  M G Masucci; B Contreras-Salazar; E Ragnar; K Falk; J Minarovits; I Ernberg; G Klein
Journal:  J Virol       Date:  1989-07       Impact factor: 5.103

6.  XVI European Charcot Foundation lecture: nutrition and environment: can MS be prevented?

Authors:  Kelly Claire Simon; Kassandra L Munger; Alberto Ascherio
Journal:  J Neurol Sci       Date:  2011-10-04       Impact factor: 3.181

Review 7.  Epstein-Barr virus and human diseases: recent advances in diagnosis.

Authors:  M Okano; G M Thiele; J R Davis; H L Grierson; D T Purtilo
Journal:  Clin Microbiol Rev       Date:  1988-07       Impact factor: 26.132

8.  Eradication of Epstein-Barr virus by allogeneic bone marrow transplantation: implications for sites of viral latency.

Authors:  J W Gratama; M A Oosterveer; F E Zwaan; J Lepoutre; G Klein; I Ernberg
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

9.  Variable expression of latent membrane protein in nasopharyngeal carcinoma can be related to methylation status of the Epstein-Barr virus BNLF-1 5'-flanking region.

Authors:  L F Hu; J Minarovits; S L Cao; B Contreras-Salazar; L Rymo; K Falk; G Klein; I Ernberg
Journal:  J Virol       Date:  1991-03       Impact factor: 5.103

10.  Dual EBNA1 promoter usage by Epstein-Barr virus in human B-cell lines expressing unique intermediate cellular phenotypes.

Authors:  K A Taylor; S Wetzel; D S Lyles; B A Pollok
Journal:  J Virol       Date:  1994-10       Impact factor: 5.103
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