Shanliang Zhong1, Jinyan Wang2, Junchen Hou2, Qian Zhang2, Hanzi Xu3, Jiahua Hu1, Jianhua Zhao1, Jifeng Feng4. 1. Center of Clinical Laboratory Science, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing 210009, PR China. 2. Department of General Surgery, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing 210009, PR China. 3. Department of Radiation Oncology, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & Nanjing Medical University Affiliated Cancer Hospital, Nanjing 210009, PR China. 4. Department of Medical Oncology, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing 210009, PR China.
Abstract
AIM: We aimed to explore the roles of circRNAs in gastric cancer. MATERIALS & METHODS: The dysregulated circRNAs and miRNAs were identified using data from Gene Expression Omnibus. The roles of specifically selected circRNAs were explored. Survival analysis was performed using data from the Cancer Genome Atlas. RESULTS: We identified 68 dysregulated circRNAs and 51 dysregulated miRNAs. We found that hsa_circ_0000993 inhibited migration, invasion and proliferation of gastric cancer cells and could act as a miRNA sponge for miR-214-5p but did not modulate expression of its parental gene, ATL2. Survival analysis showed that gastric cancer patients with lowly expressed miR-214-5p had a significantly better overall survival. CONCLUSION: In conclusion, hsa_circ_0000993 may inhibit metastasis of gastric cancer through sequestering miR-214-5p.
AIM: We aimed to explore the roles of circRNAs in gastric cancer. MATERIALS & METHODS: The dysregulated circRNAs and miRNAs were identified using data from Gene Expression Omnibus. The roles of specifically selected circRNAs were explored. Survival analysis was performed using data from the Cancer Genome Atlas. RESULTS: We identified 68 dysregulated circRNAs and 51 dysregulated miRNAs. We found that hsa_circ_0000993 inhibited migration, invasion and proliferation of gastric cancer cells and could act as a miRNA sponge for miR-214-5p but did not modulate expression of its parental gene, ATL2. Survival analysis showed that gastric cancerpatients with lowly expressed miR-214-5p had a significantly better overall survival. CONCLUSION: In conclusion, hsa_circ_0000993 may inhibit metastasis of gastric cancer through sequestering miR-214-5p.