Literature DB >> 30215293

Spinal Progenitor-Laden Bridges Support Earlier Axon Regeneration Following Spinal Cord Injury.

Courtney M Dumont1, Mary K Munsell1, Mitchell A Carlson1, Brian J Cummings2,3,4,5, Aileen J Anderson2,3,4,5, Lonnie D Shea1,6.   

Abstract

IMPACT STATEMENT: Spinal cord injury (SCI) results in loss of tissue innervation below the injury. Spinal progenitors have a greater ability to repair the damage and can be injected into the injury, but their regenerative potential is hampered by their poor survival after transplantation. Biomaterials can create a cell delivery platform and generate a more hospitable microenvironment for the progenitors within the injury. In this work, polymeric bridges are used to deliver embryonic spinal progenitors to the injury, resulting in increased progenitor survival and subsequent regeneration and functional recovery, thus demonstrating the importance of combined therapeutic approaches for SCI.

Entities:  

Keywords:  axon elongation; biomaterial; spinal cord injury; spinal progenitor cells

Mesh：

Substances：

Year:  2018        PMID： 30215293      PMCID： PMC6238608          DOI： 10.1089/ten.TEA.2018.0053

Source DB:  PubMed          Journal:  Tissue Eng Part A        ISSN： 1937-3341            Impact factor:   3.845


  83 in total

1.  Delivery of neurotrophin-3 from fibrin enhances neuronal fiber sprouting after spinal cord injury.

Authors:  Sara J Taylor; Ephron S Rosenzweig; John W McDonald; Shelly E Sakiyama-Elbert
Journal:  J Control Release       Date:  2006-06-22       Impact factor: 9.776

2.  Multiple channel bridges for spinal cord injury: cellular characterization of host response.

Authors:  Yang Yang; Laura De Laporte; Marina L Zelivyanskaya; Kevin J Whittlesey; Aileen J Anderson; Brian J Cummings; Lonnie D Shea
Journal:  Tissue Eng Part A       Date:  2009-11       Impact factor: 3.845

3.  Extramedullary chitosan channels promote survival of transplanted neural stem and progenitor cells and create a tissue bridge after complete spinal cord transection.

Authors:  Hiroshi Nomura; Tasneem Zahir; Howard Kim; Yusuke Katayama; Iris Kulbatski; Cindi M Morshead; Molly S Shoichet; Charles H Tator
Journal:  Tissue Eng Part A       Date:  2008-05       Impact factor: 3.845

4.  Age-related proteomic changes in the subventricular zone and their association with neural stem/progenitor cell proliferation.

Authors:  Melissa J McGinn; Raymond J Colello; Dong Sun
Journal:  J Neurosci Res       Date:  2012-02-16       Impact factor: 4.164

Review 5.  A systematic review of cellular transplantation therapies for spinal cord injury.

Authors:  Wolfram Tetzlaff; Elena B Okon; Soheila Karimi-Abdolrezaee; Caitlin E Hill; Joseph S Sparling; Jason R Plemel; Ward T Plunet; Eve C Tsai; Darryl Baptiste; Laura J Smithson; Michael D Kawaja; Michael G Fehlings; Brian K Kwon
Journal:  J Neurotrauma       Date:  2010-04-20       Impact factor: 5.269

6.  Propriospinal fibers in the rat.

Authors:  K Chung; R E Coggeshall
Journal:  J Comp Neurol       Date:  1983-06-10       Impact factor: 3.215

7.  FGF-2-responsive neural stem cell proliferation requires CCg, a novel autocrine/paracrine cofactor.

Authors:  P Taupin; J Ray; W H Fischer; S T Suhr; K Hakansson; A Grubb; F H Gage
Journal:  Neuron       Date:  2000-11       Impact factor: 17.173

8.  Repair of the injured spinal cord by transplantation of neural stem cells in a hyaluronan-based hydrogel.

Authors:  Andrea J Mothe; Roger Y Tam; Tasneem Zahir; Charles H Tator; Molly S Shoichet
Journal:  Biomaterials       Date:  2013-03-07       Impact factor: 12.479

9.  Semi-automated counting of axon regeneration in poly(lactide co-glycolide) spinal cord bridges.

Authors:  Dylan A McCreedy; Daniel J Margul; Stephanie K Seidlits; Jennifer T Antane; Ryan J Thomas; Gillian M Sissman; Ryan M Boehler; Dominique R Smith; Sam W Goldsmith; Todor V Kukushliev; Jonathan B Lamano; Bansi H Vedia; Ting He; Lonnie D Shea
Journal:  J Neurosci Methods       Date:  2016-01-25       Impact factor: 2.390

10.  Preclinical Efficacy Failure of Human CNS-Derived Stem Cells for Use in the Pathway Study of Cervical Spinal Cord Injury.

Authors:  Aileen J Anderson; Katja M Piltti; Mitra J Hooshmand; Rebecca A Nishi; Brian J Cummings
Journal:  Stem Cell Reports       Date:  2017-02-14       Impact factor: 7.765
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  5 in total

1.  Polycistronic Delivery of IL-10 and NT-3 Promotes Oligodendrocyte Myelination and Functional Recovery in a Mouse Spinal Cord Injury Model.

Authors:  Dominique R Smith; Courtney M Dumont; Jonghyuck Park; Andrew J Ciciriello; Amina Guo; Ravindra Tatineni; Brian J Cummings; Aileen J Anderson; Lonnie D Shea
Journal:  Tissue Eng Part A       Date:  2020-02-25       Impact factor: 3.845

Review 2.  Regenerative Therapies for Spinal Cord Injury.

Authors:  Nureddin Ashammakhi; Han-Jun Kim; Arshia Ehsanipour; Rebecca D Bierman; Outi Kaarela; Chengbin Xue; Ali Khademhosseini; Stephanie K Seidlits
Journal:  Tissue Eng Part B Rev       Date:  2019-10-23       Impact factor: 6.389

3.  IL-10 lentivirus-laden hydrogel tubes increase spinal progenitor survival and neuronal differentiation after spinal cord injury.

Authors:  Andrew J Ciciriello; Dominique R Smith; Mary K Munsell; Sydney J Boyd; Lonnie D Shea; Courtney M Dumont
Journal:  Biotechnol Bioeng       Date:  2021-04-23       Impact factor: 4.395

4.  Acute Implantation of Aligned Hydrogel Tubes Supports Delayed Spinal Progenitor Implantation.

Authors:  Andrew J Ciciriello; Dominique R Smith; Mary K Munsell; Sydney J Boyd; Lonnie D Shea; Courtney M Dumont
Journal:  ACS Biomater Sci Eng       Date:  2020-09-14

5.  Resveratrol promotes axonal regeneration after spinal cord injury through activating Wnt/β-catenin signaling pathway.

Authors:  Zimin Xiang; Shuai Zhang; Xiaodong Yao; Libin Xu; Jianwei Hu; Chenghui Yin; Jianmei Chen; Hao Xu
Journal:  Aging (Albany NY)       Date:  2021-10-14       Impact factor: 5.682
  5 in total

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