Literature DB >> 30215281

Novel bacterial topoisomerase inhibitors: challenges and perspectives in reducing hERG toxicity.

Anja Kolarič1,2, Nikola Minovski1.   

Abstract

Entities:  

Keywords:  NBTIs optimization; bacterial DNA gyrase; intercalating antibacterial agents; novel bacterial topoisomerase inhibitors; reducing hERG toxicity; structure–activity relationship

Mesh：

Substances：

Year:  2018        PMID： 30215281     DOI： 10.4155/fmc-2018-0272

Source DB:  PubMed          Journal:  Future Med Chem        ISSN： 1756-8919            Impact factor:   3.808


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  4 in total

1.  1,3-Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Expanding Structural Diversity and the Antibacterial Spectrum.

Authors:  Yanran Lu; Chelsea A Mann; Sheri Nolan; Jessica A Collins; Elizabeth Parker; Jonathan Papa; Sandip Vibhute; Seyedehameneh Jahanbakhsh; Mary Thwaites; David Hufnagel; Manzour H Hazbón; Jane Moreno; Timothy T Stedman; Thomas Wittum; Daniel J Wozniak; Neil Osheroff; Jack C Yalowich; Mark J Mitton-Fry
Journal:  ACS Med Chem Lett       Date:  2022-05-09       Impact factor: 4.632

Review 2.  Two Decades of Successful SAR-Grounded Stories of the Novel Bacterial Topoisomerase Inhibitors (NBTIs).

Authors:  Anja Kolarič; Marko Anderluh; Nikola Minovski
Journal:  J Med Chem       Date:  2020-02-17       Impact factor: 7.446

Review 3.  DNA Topoisomerase Inhibitors: Trapping a DNA-Cleaving Machine in Motion.

Authors:  Benjamin D Bax; Garib Murshudov; Anthony Maxwell; Thomas Germe
Journal:  J Mol Biol       Date:  2019-07-10       Impact factor: 5.469

Review 4.  The Structural Features of Novel Bacterial Topoisomerase Inhibitors That Define Their Activity on Topoisomerase IV.

Authors:  Maja Kokot; Marko Anderluh; Martina Hrast; Nikola Minovski
Journal:  J Med Chem       Date:  2022-05-03       Impact factor: 8.039
  4 in total

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