Literature DB >> 3021474

Effects of chronic treatment with benzodiazepine receptor ligands on cortical adrenoceptors.

S C Stanford, H J Little, D J Nutt, S C Taylor.   

Abstract

We report the effects of kindling with the benzodiazepine partial inverse agonist, FG 7142 on adrenoceptor binding in mouse cerebral cortex. Twelve once-daily injections of FG 7142 caused a statistically significant increase in the density of both alpha 2- and beta-adrenoceptor binding sites, seven days after the last injection. Despite the marked effects of FG 7142 on adrenoceptors, there were no changes in either alpha 2- or beta-adrenoceptor binding after prolonged treatment with the benzodiazepine, flurazepam.

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Year:  1986        PMID： 3021474     DOI： 10.1016/0014-2999(86)90351-1

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  3 in total

1.  Effects of a single or repeated administration of the benzodiazepine inverse agonist FG7142 on behaviour and cortical adrenoceptor binding in the rat.

Authors:  S C Stanford; H A Baldwin; S E File
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

2.  Effects of GABAA receptor ligands on noradrenaline concentration and beta-adrenoceptor binding in mouse cerebral cortex.

Authors:  D Gettins; N Goldsack; V Ibegbuna; S C Stanford
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

3.  Acetylcholinesterase activity in regions of mouse brain following acute and chronic treatment with a benzodiazepine inverse agonist.

Authors:  M E Appleyard; S C Taylor; H J Little
Journal:  Br J Pharmacol       Date:  1990-11       Impact factor: 8.739
  3 in total

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