| Literature DB >> 30213884 |
Daniel DiToro1, Colleen J Winstead1, Duy Pham1, Steven Witte1, Rakieb Andargachew2, Jeffrey R Singer1, C Garrett Wilson1, Carlene L Zindl1, Rita J Luther1, Daniel J Silberger1, Benjamin T Weaver3, E Motunrayo Kolawole2, Ryan J Martinez2, Henrietta Turner1, Robin D Hatton1, James J Moon4, Sing Sing Way5, Brian D Evavold2, Casey T Weaver6.
Abstract
In response to infection, naïve CD4+ T cells differentiate into two subpopulations: T follicular helper (TFH) cells, which support B cell antibody production, and non-TFH cells, which enhance innate immune cell functions. Interleukin-2 (IL-2), the major cytokine produced by naïve T cells, plays an important role in the developmental divergence of these populations. However, the relationship between IL-2 production and fate determination remains unclear. Using reporter mice, we found that differential production of IL-2 by naïve CD4+ T cells defined precursors fated for different immune functions. IL-2 producers, which were fated to become TFH cells, delivered IL-2 to nonproducers destined to become non-TFH cells. Because IL-2 production was limited to cells receiving the strongest T cell receptor (TCR) signals, a direct link between TCR-signal strength, IL-2 production, and T cell fate determination has been established.Entities:
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Year: 2018 PMID： 30213884 PMCID： PMC6501592 DOI： 10.1126/science.aao2933
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728