| Literature DB >> 3021280 |
B A Brooks, A F Fuchs, D Finocchio.
Abstract
Saccadic eye tracking was studied in a monkey given i.v. injections of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The Parkinson-like symptoms which appeared in the animal's general motor behavior (akinesia, bradykinesia, hypokinesia) were also observed in its eye tracking. Similar oculomotor deficits are seen in patients with idiopathic Parkinsonism. The MPTP model offers excellent possibilities for studying the mechanisms underlying the motor disabilities of Parkinson's disease.Entities:
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Year: 1986 PMID： 3021280 DOI： 10.1016/0006-8993(86)90049-1
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252