Conall OʼCleirigh1,2, Michael J Zvolensky3,4, Jasper A J Smits5, Allison K Labbe1,2, Jessica N Coleman1,6, Julianne G Wilner1,7, Amelia M Stanton5, Adam Gonzalez8, Lorra Garey3, Kristen S Regenauer1, David Rosenfield9. 1. Department of Psychiatry, Massachusetts General Hospital, Boston, MA. 2. Harvard Medical School, Boston, MA. 3. Department of Psychology, University of Houston, Houston, TX. 4. Department of Behavioral Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX. 5. Department of Psychology, University of Texas at Austin, Austin, TX. 6. Department of Psychology & Neuroscience, Duke University, Durham, NC. 7. Department of Psychological & Brain Sciences, Boston University, Boston, MA. 8. Department of Psychiatry, SUNY Stony Brook School of Medicine, Stony Brook, NY. 9. Department of Psychology, Southern Methodist University, Dallas, TX.
Abstract
OBJECTIVE: Among people living with HIV, cigarette smoking rates are higher than among the general population, and anxiety, depression, and their disorders are common and associated with smoking and poorer outcomes during cessation. This study evaluated the efficacy of an integrated smoking cessation intervention, developed to target anxiety, depression, and smoking cessation concurrently among people living with HIV. METHOD:Smokers living with HIV who reported at least moderate motivation to quit smoking were randomized into a novel 9-week integrated intervention (QUIT), consisting of 1 psychoeducation (prerandomization) session and 9 weekly 1-hour sessions of cognitive behavioral therapy for smoking cessation and anxiety/depression plus nicotine replacement therapy, or a 9-week enhanced standard smoking intervention (ETAU), consisting of 1 psychoeducation session (prerandomization) and 4 brief weekly check-in sessions plus nicotine replacement therapy. All were instructed to make a quit attempt at week 6. RESULTS:Seventy-two participants were enrolled, and 53 were randomized. 41/53 participants completed the active treatment phase of the study. 7-day point-prevalence abstinence, verified with expired carbon monoxide, was significantly higher among those in the integrated intervention than those in the enhanced standard intervention both end-of-treatment {[MQUIT = 59%, METAU = 9%; b = 5.60, 95% confidence interval: (2.64 to 8.56), t(332) = 3.72, P < 0.001]} and 6-months post-quit date {[MQUIT = 46%, METAU = 5%; b = 7.69, 95% confidence interval: (4.60 to 10.78), t(332) = 4.90, P < 0.001]}. Consideration of patterns of missingness did not alter the significance of these findings. CONCLUSIONS: The integrated intervention was associated with substantially higher short-term and long-term abstinence rates than the enhanced standard intervention. These data provide promising initial evidence supporting the benefits of an integrated anxiety-depression/smoking cessation program specifically tailored for people living with HIV.
RCT Entities:
OBJECTIVE: Among people living with HIV, cigarette smoking rates are higher than among the general population, and anxiety, depression, and their disorders are common and associated with smoking and poorer outcomes during cessation. This study evaluated the efficacy of an integrated smoking cessation intervention, developed to target anxiety, depression, and smoking cessation concurrently among people living with HIV. METHOD: Smokers living with HIV who reported at least moderate motivation to quit smoking were randomized into a novel 9-week integrated intervention (QUIT), consisting of 1 psychoeducation (prerandomization) session and 9 weekly 1-hour sessions of cognitive behavioral therapy for smoking cessation and anxiety/depression plus nicotine replacement therapy, or a 9-week enhanced standard smoking intervention (ETAU), consisting of 1 psychoeducation session (prerandomization) and 4 brief weekly check-in sessions plus nicotine replacement therapy. All were instructed to make a quit attempt at week 6. RESULTS: Seventy-two participants were enrolled, and 53 were randomized. 41/53 participants completed the active treatment phase of the study. 7-day point-prevalence abstinence, verified with expired carbon monoxide, was significantly higher among those in the integrated intervention than those in the enhanced standard intervention both end-of-treatment {[MQUIT = 59%, METAU = 9%; b = 5.60, 95% confidence interval: (2.64 to 8.56), t(332) = 3.72, P < 0.001]} and 6-months post-quit date {[MQUIT = 46%, METAU = 5%; b = 7.69, 95% confidence interval: (4.60 to 10.78), t(332) = 4.90, P < 0.001]}. Consideration of patterns of missingness did not alter the significance of these findings. CONCLUSIONS: The integrated intervention was associated with substantially higher short-term and long-term abstinence rates than the enhanced standard intervention. These data provide promising initial evidence supporting the benefits of an integrated anxiety-depression/smoking cessation program specifically tailored for people living with HIV.
Authors: J S Lee; S A Bainter; A W Carrico; T R Glynn; B G Rogers; C Albright; C O'Cleirigh; K H Mayer; S A Safren Journal: J Behav Med Date: 2020-05-02
Authors: Jasper A J Smits; Michael J Zvolensky; Michael W Otto; Megan E Piper; Scarlett O Baird; Brooke Y Kauffman; Eunjung Lee-Furman; Noura Alavi; Christina D Dutcher; Santiago Papini; Benjamin Rosenfield; David Rosenfield Journal: Drug Alcohol Depend Date: 2020-01-22 Impact factor: 4.492
Authors: Lisa R LaRowe; John D Cleveland; Dustin M Long; Shadi Nahvi; Edward R Cachay; Katerina A Christopoulos; Heidi M Crane; Karen Cropsey; Sonia Napravnik; Conall O'Cleirigh; Jessica S Merlin; Joseph W Ditre Journal: AIDS Care Date: 2021-02-17
Authors: Taghrid Asfar; Amanda Perez; Patrick Shipman; Adam W Carrico; David J Lee; Maria Luisa Alcaide; Deborah L Jones; Judson Brewer; Tulay Koru-Sengul Journal: Nicotine Tob Res Date: 2021-08-04 Impact factor: 4.244
Authors: Amelia M Stanton; Jasper S Lee; Megan R Wirtz; Lena S Andersen; John Joska; Steven A Safren; Richard van Zyl-Smit; Conall O'Cleirigh Journal: Int J Behav Med Date: 2021-01-28
Authors: Natalie E Chichetto; Brittanny M Polanka; Kaku A So-Armah; Minhee Sung; Jesse C Stewart; John R Koethe; E Jennifer Edelman; Hilary A Tindle; Matthew S Freiberg Journal: Curr HIV/AIDS Rep Date: 2020-08 Impact factor: 5.495
Authors: Conall O'Cleirigh; Dana King; Amelia M Stanton; Amanda Goldin; Norik Kirakosian; Heidi M Crane; Chris Grasso Journal: J Community Health Date: 2021-07-02