Oscar Diaz-Cambronero1,2, Guido Mazzinari2,3, Juan P Cata4,5. 1. Department of Anesthesiology, Hospital Universitari i Politecnic la Fe, Valencia, Spain. 2. Perioperative Medicine Research Group, Instituto de Investigación Sanitaria La Fe (IIS la Fe). 3. Department of Anesthesiology, Hospital de Manises, Valencia, Spain. 4. Department of Anesthesiology & Perioperative Medicine, The University of Texas-MD Anderson Cancer Center, Houston, TX, USA. 5. Anesthesia & Surgical Oncology Research Group, Houston, TX, USA.
Abstract
AIM: To summarize the literature on the long-term impact of perioperative opioids in colorectal cancer. MATERIALS & METHODS: Combined results from two searching strategies in PubMed/MEDLINE (1950-2018), based on a PICO approach; P: Opioid influence on cancer-related long-term outcome in patient undergoing colorectal surgery; I: Opioid drugs administered in the perioperative period; C: Correlation between dose and/or type of opioid with long-term oncologic outcome; O: Disease-free survival and/or overall survival (OS). RESULTS: Thirteen articles fulfilled the predetermined inclusion criteria. Due to the heterogeneity of the different studies, a quantitative meta-analysis to sum the evidence was deemed unfeasible. CONCLUSION: Our review indicates that there is no conclusive evidence to avoid the use of opioids with the goal of reducing the risk of recurrence in colorectal cancer.
AIM: To summarize the literature on the long-term impact of perioperative opioids in colorectal cancer. MATERIALS & METHODS: Combined results from two searching strategies in PubMed/MEDLINE (1950-2018), based on a PICO approach; P: Opioid influence on cancer-related long-term outcome in patient undergoing colorectal surgery; I: Opioid drugs administered in the perioperative period; C: Correlation between dose and/or type of opioid with long-term oncologic outcome; O: Disease-free survival and/or overall survival (OS). RESULTS: Thirteen articles fulfilled the predetermined inclusion criteria. Due to the heterogeneity of the different studies, a quantitative meta-analysis to sum the evidence was deemed unfeasible. CONCLUSION: Our review indicates that there is no conclusive evidence to avoid the use of opioids with the goal of reducing the risk of recurrence in colorectal cancer.
Authors: Jadie Plücker; Naita M Wirsik; Alina S Ritter; Thomas Schmidt; Markus A Weigand Journal: Langenbecks Arch Surg Date: 2021-02-01 Impact factor: 3.445