| Literature DB >> 30211959 |
Masahiro Kawada1, Kosuke Nakashima1, Shin-Ichi Hirashima1, Toru Sakagami1, Yuji Koseki1, Tsuyoshi Miura1.
Abstract
In this study, stereoselective conjugate addition of ketones to alkylidene malonates using organocatalyst has been developed. The reaction in the presence of 20 mol% of a novel thiourea-sulfonamide organocatalyst afforded conjugate adducts in moderate to high yields (up to 81%) under mild reaction conditions. Excellent diastereoselectivity (up to 98:2 dr) and enantioselectivity (up to 88% ee) were achieved.Entities:
Keywords: alkylidene malonate; asymmetric conjugate addition; organocatalysis; organocatalyst; thiourea-sulfonamideIntroduction
Year: 2018 PMID： 30211959 DOI： 10.1002/chir.23015
Source DB: PubMed Journal: Chirality ISSN： 0899-0042 Impact factor: 2.437