| Literature DB >> 3021035 |
J R Graybill, E Palou, J Ahrens.
Abstract
Fluconazole was compared with ketoconazole and with amphotericin B in treatment of pulmonary histoplasmosis in immunologically intact mice and in congenitally athymic nude mice. Both fluconazole and amphotericin B increased survival and reduced fungal burden in normal mice. All 3 drugs equally prolonged survival of nude mice challenged with Histoplasma capsulatum, and all effectively reduced the fungal burden. Fluconazole may be a useful antifungal drug in treatment of murine histoplasmosis.Entities:
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Year: 1986 PMID： 3021035 DOI： 10.1164/arrd.1986.134.4.768
Source DB: PubMed Journal: Am Rev Respir Dis ISSN： 0003-0805