Fabrizio Guerra1, Marta Mazur2, Artnora Ndokaj1, Denise Corridore1, Giuseppe La Torre3, Antonella Polimeni1, Livia Ottolenghi1. 1. Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy. 2. Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy - marta.mazur@uniroma1.it. 3. Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Abstract
INTRODUCTION: The association between the oral microbiome and periodontal diseases is still unclear. We performed a systematic review and meta-analysis to quantify the association between the specific pathogens and periodontitis. EVIDENCE ACQUISITION: A computerized medical search was performed using MEDLINE and SCOPUS database between 1950 and May 2017 to identify all case-control studies that evaluated the association between specific pathogens and periodontitis. The pooled Odds Ratio with relative 95% confidence interval (95% CI) was calculated and plotted in the forest plot. EVIDENCE SYNTHESIS: Eleven RCTs involving 2111 patients were included. The retrieved case-control studies evaluated the presence or absence of different targeted pathogens. Among the microrganisms evaluated Porphyromonas gengivalis (OR [95% CI] 2.93 [0.98,8.87]; P<0.0001) and Streptococcus mutans (OR [95% CI] 1.77 [0.89-3.54]; P=0.03) were found to be risk factors for the development of periodontitis, while Aggregatibacter actinomycetemcomitans (OR [95% CI] 0.52 [0.33-0.83]) played a protective role for periodontitis. CONCLUSIONS: It seems that changes in the taxonomic composition of the microbiome rather than single targeted pathogens is the key determinant of periodontitis.
INTRODUCTION: The association between the oral microbiome and periodontal diseases is still unclear. We performed a systematic review and meta-analysis to quantify the association between the specific pathogens and periodontitis. EVIDENCE ACQUISITION: A computerized medical search was performed using MEDLINE and SCOPUS database between 1950 and May 2017 to identify all case-control studies that evaluated the association between specific pathogens and periodontitis. The pooled Odds Ratio with relative 95% confidence interval (95% CI) was calculated and plotted in the forest plot. EVIDENCE SYNTHESIS: Eleven RCTs involving 2111 patients were included. The retrieved case-control studies evaluated the presence or absence of different targeted pathogens. Among the microrganisms evaluated Porphyromonas gengivalis (OR [95% CI] 2.93 [0.98,8.87]; P<0.0001) and Streptococcus mutans (OR [95% CI] 1.77 [0.89-3.54]; P=0.03) were found to be risk factors for the development of periodontitis, while Aggregatibacter actinomycetemcomitans (OR [95% CI] 0.52 [0.33-0.83]) played a protective role for periodontitis. CONCLUSIONS: It seems that changes in the taxonomic composition of the microbiome rather than single targeted pathogens is the key determinant of periodontitis.
Authors: Gianna Maria Nardi; Marta Mazur; Giulio Papa; Massimo Petruzzi; Felice Roberto Grassi; Roberta Grassi Journal: Int J Environ Res Public Health Date: 2022-05-07 Impact factor: 4.614