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Literature DB >> 30207319

Role of miRNAs in hypoxia-related disorders.

A Gupta¹, R Sugadev, Y K Sharma, Y Yahmad, P Khurana.

Abstract

Hypoxia is a complex pathophysiological condition. The physiological and molecular responses to this stress have been extensively studied. However, the management of its ill effects still poses a challenge to clinicians. MicroRNAs (miRNAs) are short non-coding RNA molecules that control post-transcriptional gene expression. The regulatory role of miRNAs in hypoxic environments has been studied in many hypoxia-related disorders, however a comprehensive compilation and analysis of all data and the significance of miRNAs in hypoxia adaption is still lacking. This review summarizes the miRNAs related to various hypoxia-related disorders and highlights the computational approaches to study them. This would help in designing novel strategies toward efficient management of hypoxia-related disorders.

Entities: Disease

Mesh：

Substances：
MicroRNAs

Year: 2018 PMID： 30207319

Source DB: PubMed Journal: J Biosci ISSN： 0250-5991 Impact factor: 1.826

76 in total

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Authors: Yuk Cheung Chan; Savita Khanna; Sashwati Roy; Chandan K Sen
Journal: J Biol Chem Date: 2010-11-16 Impact factor: 5.157

Review 2. Interplay between receptor tyrosine kinases and hypoxia signaling in cancer.

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Journal: Am J Physiol Cell Physiol Date: 2015-10-21 Impact factor: 4.249

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Journal: Semin Cell Dev Biol Date: 2012-10-10 Impact factor: 7.727

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Journal: Int J Mol Sci Date: 2016-04-06 Impact factor: 5.923

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Authors: Pannapa Pinweha; Khanti Rattanapornsompong; Varodom Charoensawan; Sarawut Jitrapakdee
Journal: Comput Struct Biotechnol J Date: 2016-06-04 Impact factor: 7.271

8. Effect of Hypoxia on the Differentiation and the Self-Renewal of Metanephrogenic Mesenchymal Stem Cells.

Authors: Shaopeng Liu; Nana Song; Jianqiang He; Xiaofang Yu; Jia Guo; Xiaoyan Jiao; Xiaoqiang Ding; Jie Teng
Journal: Stem Cells Int Date: 2017-01-17 Impact factor: 5.443

9. Regulation of HIF-1alpha and VEGF by miR-20b tunes tumor cells to adapt to the alteration of oxygen concentration.

Authors: Zhang Lei; Bo Li; Zhuoshun Yang; Haoshu Fang; Gui-Mei Zhang; Zuo-Hua Feng; Bo Huang
Journal: PLoS One Date: 2009-10-29 Impact factor: 3.240

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Authors: Hani Choudhry; Adrian L Harris; Alan McIntyre
Journal: Mol Aspects Med Date: 2016-01-21

3 in total

1. nSARS-Cov-2, pulmonary edema and thrombosis: possible molecular insights using miRNA-gene circuits in regulatory networks.

Authors: P Khurana; A Gupta; R Sugadev; Y K Sharma; R Varshney; L Ganju; B Kumar
Journal: ExRNA Date: 2020-10-30

2. HAHmiR.DB: a server platform for high-altitude human miRNA-gene coregulatory networks and associated regulatory circuits.

Authors: Pankaj Khurana; Apoorv Gupta; Ragumani Sugadev; Yogendra Kumar Sharma; Bhuvnesh Kumar
Journal: Database (Oxford) Date: 2020-12-01 Impact factor: 3.451

Review 3. The role of hypoxia-associated miRNAs in acquired sensorineural hearing loss.

Authors: Sina Safabakhsh; Printha Wijesinghe; Morgan Nunez; Desmond A Nunez
Journal: Front Cell Neurosci Date: 2022-08-05 Impact factor: 6.147

3 in total