D Luan1, D Wang1, H Campos2, A Baylin3. 1. Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA. 2. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Centro de Investigación e Innovación en Nutricion Traslacional y Salud, Universidad Hispanoamericana, San Jose, Costa Rica. 3. Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA; Department of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: abaylin@umich.edu.
Abstract
BACKGROUND AND AIMS: Animal models have shown that adipose-derived palmitoleic acid may act as a lipokine by conferring resistance to diet-induced obesity; however, human epidemiologic studies investigating this relationship thus far have not provided data in support of this hypothesis. Because metabolic syndrome and cardiovascular disease are intricately linked with the former being a major risk factor for the latter, we hypothesized that adipose-derived palmitoleic acid may be inversely associated with myocardial infarction. We examined whether adipose tissue palmitoleic acid was associated with nonfatal acute myocardial infarction in a representative population of Costa Rican adults. METHODS AND RESULTS: Odds ratios of nonfatal acute myocardial infarction by quintiles of adipose tissue palmitoleic acid were calculated using conditional logistic regression in a case-control study of 1828 cases and 1828 controls matched by age, sex, and area of residence. We observed an inverse relationship between nonfatal acute myocardial infarction and adipose tissue palmitoleic acid (OR for highest quintile compared to lowest quintile of palmitoleic acid: 0.55; 95% CI: 0.41, 0.75; P for trend: <0.0001). We additionally observed a significant positive association between adipose tissue palmitoleic acid and high-density lipoprotein cholesterol. CONCLUSION: These data demonstrate an inverse association between adipose tissue palmitoleic acid and nonfatal acute myocardial infarction; however, further research is required in order to better understand the opposing associations between palmitoleic acid and high-density lipoprotein cholesterol and systolic blood pressure.
BACKGROUND AND AIMS: Animal models have shown that adipose-derived palmitoleic acid may act as a lipokine by conferring resistance to diet-induced obesity; however, human epidemiologic studies investigating this relationship thus far have not provided data in support of this hypothesis. Because metabolic syndrome and cardiovascular disease are intricately linked with the former being a major risk factor for the latter, we hypothesized that adipose-derived palmitoleic acid may be inversely associated with myocardial infarction. We examined whether adipose tissue palmitoleic acid was associated with nonfatal acute myocardial infarction in a representative population of Costa Rican adults. METHODS AND RESULTS: Odds ratios of nonfatal acute myocardial infarction by quintiles of adipose tissue palmitoleic acid were calculated using conditional logistic regression in a case-control study of 1828 cases and 1828 controls matched by age, sex, and area of residence. We observed an inverse relationship between nonfatal acute myocardial infarction and adipose tissue palmitoleic acid (OR for highest quintile compared to lowest quintile of palmitoleic acid: 0.55; 95% CI: 0.41, 0.75; P for trend: <0.0001). We additionally observed a significant positive association between adipose tissue palmitoleic acid and high-density lipoprotein cholesterol. CONCLUSION: These data demonstrate an inverse association between adipose tissue palmitoleic acid and nonfatal acute myocardial infarction; however, further research is required in order to better understand the opposing associations between palmitoleic acid and high-density lipoprotein cholesterol and systolic blood pressure.
Authors: Majken K Jensen; Sarah A Aroner; Kenneth J Mukamal; Jeremy D Furtado; Wendy S Post; Michael Y Tsai; Anne Tjønneland; Joseph F Polak; Eric B Rimm; Kim Overvad; Robyn L McClelland; Frank M Sacks Journal: Circulation Date: 2017-11-21 Impact factor: 29.690
Authors: F B Hu; M J Stampfer; J E Manson; E B Rimm; A Wolk; G A Colditz; C H Hennekens; W C Willett Journal: Am J Clin Nutr Date: 1999-05 Impact factor: 7.045
Authors: Dariush Mozaffarian; Haiming Cao; Irena B King; Rozenn N Lemaitre; Xiaoling Song; David S Siscovick; Gökhan S Hotamisligil Journal: Am J Clin Nutr Date: 2010-10-13 Impact factor: 7.045
Authors: Jordi Mayneris-Perxachs; Marcela Guerendiain; Ana I Castellote; Ramón Estruch; María Isabel Covas; Montserrat Fitó; Jordi Salas-Salvadó; Miguel A Martínez-González; Fernando Aros; Rosa M Lamuela-Raventós; M Carmen López-Sabater Journal: Clin Nutr Date: 2013-03-28 Impact factor: 7.324
Authors: F B Hu; M J Stampfer; J E Manson; E Rimm; G A Colditz; B A Rosner; C H Hennekens; W C Willett Journal: N Engl J Med Date: 1997-11-20 Impact factor: 91.245
Authors: Neil K Huang; Petra Bůžková; Nirupa R Matthan; Luc Djoussé; Calvin H Hirsch; Jorge R Kizer; W T Longstreth; Kenneth J Mukamal; Alice H Lichtenstein Journal: J Am Heart Assoc Date: 2021-03-08 Impact factor: 5.501