Literature DB >> 3020617

Eicosapentaenoic acid metabolism in human and rabbit anterior uvea.

P S Kulkarni, B D Srinivasan.   

Abstract

Eicosapentaenoic acid (EPA) metabolism into 3 series cyclooxygenase and 5 series lipoxygenase products was assessed in human and rabbit anterior uvea. Both tissues synthesized 3 series cyclooxygenase products such as delta17 6-keto-PGF1 (PGI3 metabolite), PGE3 alpha, PGE3, PGD3 and TxB3 (a stable product of TxA3) and lipoxygenase products 12-hydroxyeicosapentaenoic acid (HEPE), 5-HEPE and 5,12-diHEPE from 14C-EPA. EPA-derived cyclooxygenase product synthesis was considerably greater than the formation of lipoxygenase products from EPA in both tissues.

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Year:  1986        PMID： 3020617     DOI： 10.1016/0090-6980(86)90217-0

Source DB:  PubMed          Journal:  Prostaglandins        ISSN： 0090-6980


  6 in total

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  6 in total

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