Literature DB >> 3020587

Stimulation of interleukin 2 and interferon gamma production by leukotriene B4 in human lymphocyte cultures.

M Rola-Pleszczynski, P A Chavaillaz, I Lemaire.   

Abstract

Interleukin 2 (IL-2) and interferon-gamma (IFN) production by human lymphocytes was significantly enhanced in the presence of leukotriene B4 (LTB4) and indomethacin. Depletion of the T8+ suppressor cell subset of human T cells resulted in enhanced lymphokine production and further augmentation by LTB4. These findings suggest that LTB4 can regulate immune responses through its modulation of lymphokine production.

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Year:  1986        PMID： 3020587     DOI： 10.1016/0262-1746(86)90187-3

Source DB:  PubMed          Journal:  Prostaglandins Leukot Med        ISSN： 0262-1746


  16 in total

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4.  The immunosuppressive effects of a leukotriene B4 receptor antagonist on liver allotransplantation in rats.

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5.  Requirement for leukotriene B4 receptor 1 in allergen-induced airway hyperresponsiveness.

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8.  Dihomo-gamma-linolenic acid inhibits tumour necrosis factor-alpha production by human leucocytes independently of cyclooxygenase activity.

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9.  Influence of dietary (n-3)-polyunsaturated fatty acids on leukotriene B4 and prostaglandin E2 synthesis and course of experimental tuberculosis in guinea pigs.

Authors:  E Mayatepek; K Paul; M Leichsenring; M Pfisterer; D Wagner; M Domann; H G Sonntag; H J Bremer
Journal:  Infection       Date:  1994 Mar-Apr       Impact factor: 3.553

10.  Pharmacological control of neutrophil-mediated inflammation: strategies targeting calcium handling by activated polymorphonuclear leukocytes.

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Journal:  Drug Des Devel Ther       Date:  2009-02-06       Impact factor: 4.162
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