| Literature DB >> 30205651 |
Xiao Juan Su1,2, Lingyi Huang3, Yi Qu1,2, Dezhi Mu1,2.
Abstract
Omi/HtrA2 is a serine protease present in the mitochondrial space. When stimulated by external signals, HtrA2 is released into the mitochondrial matrix where it regulates cell death through its interaction with apoptotic and autophagic signaling pathways. Omi/HtrA2 is closely related to the pathogenesis of neurological diseases, such as neurodegeneration and hypoxic ischemic brain damage. Here, we summarize the biological characteristics of Omi/HtrA2 and its role in neurological diseases, which will provide new hints in developing Omi/HtrA2 as a therapeutic target for neurological diseases.Entities:
Keywords: apoptosis; cell death; mitochondria; neurological diseases; targeted treatment
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Year: 2019 PMID： 30205651 DOI： 10.1515/revneuro-2018-0004
Source DB: PubMed Journal: Rev Neurosci ISSN： 0334-1763 Impact factor: 4.353