Literature DB >> 30204451

Preparation of Structurally Diverse Compounds from the Natural Product Lycorine.

Sarah Z Tasker1, Amanda E Cowfer1, Paul J Hergenrother1.   

Abstract

The synthesis of a 52-member compound collection from the natural product lycorine is reported, highlighted by divergent cross-coupling and substitution strategies and an unusual ring rearrangement induced by reaction with aryne intermediates.

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Year:  2018        PMID： 30204451      PMCID： PMC6499378          DOI： 10.1021/acs.orglett.8b02562

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  8 in total

1.  Re-engineering natural products to engage new biological targets.

Authors:  Stephen E Motika; Paul J Hergenrother
Journal:  Nat Prod Rep       Date:  2020-11-18       Impact factor: 13.423

2.  Re-Engineering of Yohimbine's Biological Activity through Ring Distortion: Identification and Structure-Activity Relationships of a New Class of Antiplasmodial Agents.

Authors:  Nicholas G Paciaroni; David L Perry; Verrill M Norwood; Claribel Murillo-Solano; Jennifer Collins; Srinivasarao Tenneti; Debopam Chakrabarti; Robert W Huigens
Journal:  ACS Infect Dis       Date:  2020-01-16       Impact factor: 5.084

Review 3.  Recent Progress in Natural-Product-Inspired Programs Aimed To Address Antibiotic Resistance and Tolerance.

Authors:  Yasmeen Abouelhassan; Aaron T Garrison; Hongfen Yang; Alejandra Chávez-Riveros; Gena M Burch; Robert W Huigens
Journal:  J Med Chem       Date:  2019-04-18       Impact factor: 7.446

4.  Imidazotetrazines as Weighable Diazomethane Surrogates for Esterifications and Cyclopropanations.

Authors:  Riley L Svec; Paul J Hergenrother
Journal:  Angew Chem Int Ed Engl       Date:  2019-12-13       Impact factor: 15.336

Review 5.  Hexadehydro-Diels-Alder Reaction: Benzyne Generation via Cycloisomerization of Tethered Triynes.

Authors:  Lucas L Fluegel; Thomas R Hoye
Journal:  Chem Rev       Date:  2021-01-25       Impact factor: 60.622

6.  Limonin as a Starting Point for the Construction of Compounds with High Scaffold Diversity.

Authors:  Lucia Furiassi; Emily J Tonogai; Paul J Hergenrother
Journal:  Angew Chem Int Ed Engl       Date:  2021-06-10       Impact factor: 16.823

7.  Preventing Morphine-Seeking Behavior through the Re-Engineering of Vincamine's Biological Activity.

Authors:  Verrill M Norwood; Ariana C Brice-Tutt; Shainnel O Eans; Heather M Stacy; Guqin Shi; Ranjala Ratnayake; James R Rocca; Khalil A Abboud; Chenglong Li; Hendrik Luesch; Jay P McLaughlin; Robert W Huigens
Journal:  J Med Chem       Date:  2020-03-23       Impact factor: 7.446

8.  Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis.

Authors:  Evijola Llabani; Robert W Hicklin; Hyang Yeon Lee; Stephen E Motika; Lisa A Crawford; Eranthie Weerapana; Paul J Hergenrother
Journal:  Nat Chem       Date:  2019-05-13       Impact factor: 24.427
  8 in total

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