Paul Ernest Adams1, Matthew Francis Chersich2, Antoinette Cilliers3. 1. Division of Paediatric Cardiology, Department of Paediatrics, Chris Hani Baragwanath Academic Hospital, Soweto, and School of Clinical Medicine, University of the Witwatersrand, Johannesburg, South Africa. Email: pauleadams@gmail.com. 2. Wits Reproductive Health and HIV Institute, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Email: mcherisch@wrhi.ac.za. 3. Division of Paediatric Cardiology, Department of Paediatrics, Chris Hani Baragwanath Academic Hospital, Soweto, and School of Clinical Medicine, University of the Witwatersrand, Johannesburg, South Africa.
Abstract
BACKGROUND: Methods of closing patent ductus arteriosus (PDA) have evolved over time. We review this development in our setting. METHODS: This was a retrospective analysis of children who had transcatheter PDA closure at Chris Hani Baragwanath Hospital between 1993 and 2008. RESULTS: Over 15 years, 1 254 PDAs were diagnosed, of which 293 required intervention; 139 patients had transcatheter closure, the median age was 1.8 years (interquartile range = 1-4.5 years) and 66% were female (92/139). Mean PDA diameter was 3.2 mm (standard deviation = 1.6 mm), with an average 2:1 shunt. Transcatheter closure was performed using COOK® Flipper coils (n = 93) or Amplatzer™ devices (n = 46). Early occlusion rates for coils were 52% (39/75) and late occlusion occurred in 91% (68/75) of patients. For Amplatzer devices, early occlusion rates were 94% (33/35) and late occlusion was 100%. Amplatzer™ devices, available since 2003, were overwhelmingly used in the later years. CONCLUSIONS: Transcatheter PDA closure was safe and effective in this setting, with outcomes similar to reports elsewhere.
BACKGROUND: Methods of closing patent ductus arteriosus (PDA) have evolved over time. We review this development in our setting. METHODS: This was a retrospective analysis of children who had transcatheter PDA closure at Chris Hani Baragwanath Hospital between 1993 and 2008. RESULTS: Over 15 years, 1 254 PDAs were diagnosed, of which 293 required intervention; 139 patients had transcatheter closure, the median age was 1.8 years (interquartile range = 1-4.5 years) and 66% were female (92/139). Mean PDA diameter was 3.2 mm (standard deviation = 1.6 mm), with an average 2:1 shunt. Transcatheter closure was performed using COOK® Flipper coils (n = 93) or Amplatzer™ devices (n = 46). Early occlusion rates for coils were 52% (39/75) and late occlusion occurred in 91% (68/75) of patients. For Amplatzer devices, early occlusion rates were 94% (33/35) and late occlusion was 100%. Amplatzer™ devices, available since 2003, were overwhelmingly used in the later years. CONCLUSIONS: Transcatheter PDA closure was safe and effective in this setting, with outcomes similar to reports elsewhere.
Authors: Marjan Mosalman Haghighi; Caradee Yael Wright; Julian Ayer; Michael F Urban; Minh Duc Pham; Melanie Boeckmann; Ashtyn Areal; Bianca Wernecke; Callum P Swift; Matthew Robinson; Robyn S Hetem; Matthew F Chersich Journal: Int J Environ Res Public Health Date: 2021-05-05 Impact factor: 3.390