Literature DB >> 30204164

Synthesis and evaluation of pyrazine and quinoxaline fluorophores for in vivo detection of cerebral tau tangles in Alzheimer's models.

Biyue Zhu1, Ting Zhang, Qian Jiang, Ying Li, Yu Fu, Jiapei Dai, Ge Li, Qingrong Qi, Yan Cheng.   

Abstract

A series of pyrazine and quinoxaline probes (QNNs) were synthesized and evaluated. The quinoxaline derivative 3b, with high affinity and selectivity for tau aggregates, favorable fluorescence turn-on capability and brain kinetics, was successfully applied to the detection of tau tangles both in vitro and in mice in vivo.

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Year:  2018        PMID： 30204164     DOI： 10.1039/c8cc06897f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  3 in total

1.  Green Hydrothermal Synthesis of Fluorescent 2,3-Diarylquinoxalines and Large-Scale Computational Comparison to Existing Alternatives.

Authors:  Fabián Amaya-García; Michael Caldera; Anna Koren; Stefan Kubicek; Jörg Menche; Miriam M Unterlass
Journal:  ChemSusChem       Date:  2021-03-26       Impact factor: 8.928

2.  Synthesis, in vitro biological evaluation and molecular modelling of new 2-chloro-3-hydrazinopyrazine derivatives as potent acetylcholinesterase inhibitors‏ on PC12 cells.

Authors:  Maryam Taheri; Samira Aslani; Hossein Ghafouri; Asadollah Mohammadi; Vaha Akbary Moghaddam; Nastarn Moradi; Hananeh Naeimi
Journal:  BMC Chem       Date:  2022-02-22

3.  Rational design and synthesis of a novel BODIPY-based probe for selective imaging of tau tangles in human iPSC-derived cortical neurons.

Authors:  Alessandro Soloperto; Deborah Quaglio; Paola Baiocco; Isabella Romeo; Mattia Mori; Matteo Ardini; Caterina Presutti; Ida Sannino; Silvia Ghirga; Antonia Iazzetti; Rodolfo Ippoliti; Giancarlo Ruocco; Bruno Botta; Francesca Ghirga; Silvia Di Angelantonio; Alberto Boffi
Journal:  Sci Rep       Date:  2022-03-28       Impact factor: 4.379
  3 in total

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