Literature DB >> 30203722

A Functional Tissue-Engineered Synovium Model to Study Osteoarthritis Progression and Treatment.

Robert M Stefani1, Saiti S Halder1, Eben G Estell1, Andy J Lee1, Amy M Silverstein1, Evie Sobczak1, Nadeen O Chahine1,2, Gerard A Ateshian1,3, Roshan P Shah2, Clark T Hung1.   

Abstract

IMPACT STATEMENT: The synovium envelops the diarthrodial joint and plays a key regulatory role in defining the composition of the synovial fluid through filtration and biosynthesis of critical boundary lubricants. Synovium changes often precede cartilage damage in osteoarthritis. We describe a novel in vitro tissue engineered model, validated against native synovium explants, to investigate the structure-function of synovium through quantitative solute transport measures. Synovium was evaluated in the presence of a proinflammatory cytokine, interleukin-1, or the clinically relevant corticosteroid, dexamethasone. We anticipate that a better understanding of synovium transport would support efforts to develop more effective strategies aimed at restoring joint health.

Entities:  

Keywords:  models; osteoarthritis; solute transport; synovium

Mesh：

Substances：

Year:  2018        PMID： 30203722      PMCID： PMC6482911          DOI： 10.1089/ten.TEA.2018.0142

Source DB:  PubMed          Journal:  Tissue Eng Part A        ISSN： 1937-3341            Impact factor:   3.845


  74 in total

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Authors:  Keiichi Kuroki; Aaron M Stoker; James L Cook
Journal:  Am J Vet Res       Date:  2005-07       Impact factor: 1.156

2.  Inflammatory cytokine profiles associated with chondral damage in the anterior cruciate ligament-deficient knee.

Authors:  Paul H Marks; Michelle L Cameron Donaldson
Journal:  Arthroscopy       Date:  2005-11       Impact factor: 4.772

Review 3.  Fluid movement across synovium in healthy joints: role of synovial fluid macromolecules.

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Journal:  J Physiol       Date:  2000-07-15       Impact factor: 5.182

5.  Synovial fibroblasts self-direct multicellular lining architecture and synthetic function in three-dimensional organ culture.

Authors:  Hans P Kiener; Gerald F M Watts; Yajun Cui; John Wright; Thomas S Thornhill; Markus Sköld; Samuel M Behar; Birgit Niederreiter; Jun Lu; Manuela Cernadas; Anthony J Coyle; Gary P Sims; Josef Smolen; Matthew L Warman; Michael B Brenner; David M Lee
Journal:  Arthritis Rheum       Date:  2010-03

6.  Dexamethasone Release from Within Engineered Cartilage as a Chondroprotective Strategy Against Interleukin-1α.

Authors:  Brendan L Roach; Arta Kelmendi-Doko; Elaine C Balutis; Kacey G Marra; Gerard A Ateshian; Clark T Hung
Journal:  Tissue Eng Part A       Date:  2016-03-31       Impact factor: 3.845

7.  Guiding synovial inflammation by macrophage phenotype modulation: an in vitro study towards a therapy for osteoarthritis.

Authors:  L Utomo; G J V M van Osch; Y Bayon; J A N Verhaar; Y M Bastiaansen-Jenniskens
Journal:  Osteoarthritis Cartilage       Date:  2016-04-14       Impact factor: 6.576

8.  Decreased lubricin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injury.

Authors:  K A Elsaid; B C Fleming; H L Oksendahl; J T Machan; P D Fadale; M J Hulstyn; R Shalvoy; G D Jay
Journal:  Arthritis Rheum       Date:  2008-06

9.  The degradation of chondrogenic pellets using cocultures of synovial fibroblasts and U937 cells.

Authors:  Dominick J Blasioli; Gloria L Matthews; David L Kaplan
Journal:  Biomaterials       Date:  2013-11-10       Impact factor: 12.479

10.  The normal synovium.

Authors:  Malcolm D Smith
Journal:  Open Rheumatol J       Date:  2011-12-30
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  9 in total

1.  Sustained low-dose dexamethasone delivery via a PLGA microsphere-embedded agarose implant for enhanced osteochondral repair.

Authors:  Robert M Stefani; Andy J Lee; Andrea R Tan; Saiti S Halder; Yizhong Hu; X Edward Guo; Aaron M Stoker; Gerard A Ateshian; Kacey G Marra; James L Cook; Clark T Hung
Journal:  Acta Biomater       Date:  2019-12-02       Impact factor: 8.947

2.  Sustained Delivery of SB-431542, a Type I Transforming Growth Factor Beta-1 Receptor Inhibitor, to Prevent Arthrofibrosis.

Authors:  Andy J Lee; Christopher M Mahoney; Charles C Cai; Rika Ichinose; Robert M Stefani; Kacey G Marra; Gerard A Ateshian; Roshan P Shah; Gordana Vunjak-Novakovic; Clark T Hung
Journal:  Tissue Eng Part A       Date:  2021-05-12       Impact factor: 3.845

Review 3.  A Roadmap of In Vitro Models in Osteoarthritis: A Focus on Their Biological Relevance in Regenerative Medicine.

Authors:  Isabella Bartolotti; Livia Roseti; Mauro Petretta; Brunella Grigolo; Giovanna Desando
Journal:  J Clin Med       Date:  2021-04-28       Impact factor: 4.241

4.  Impact of Isolation Procedures on the Development of a Preclinical Synovial Fibroblasts/Macrophages in an In Vitro Model of Osteoarthritis.

Authors:  Cristina Manferdini; Yasmin Saleh; Paolo Dolzani; Elena Gabusi; Diego Trucco; Giuseppe Filardo; Gina Lisignoli
Journal:  Biology (Basel)       Date:  2020-12-10

5.  Toward Development of a Diabetic Synovium Culture Model.

Authors:  Neeraj Sakhrani; Andy J Lee; Lance A Murphy; Hagar M Kenawy; Christopher J Visco; Gerard A Ateshian; Roshan P Shah; Clark T Hung
Journal:  Front Bioeng Biotechnol       Date:  2022-02-21

6.  The Role of Synovial Membrane in the Development of a Potential In Vitro Model of Osteoarthritis.

Authors:  Denisa Harvanova; Jana Matejova; Lucia Slovinska; Marek Lacko; Slavomira Gulova; Livia Kolesar Fecskeova; Jana Janockova; Timea Spakova; Jan Rosocha
Journal:  Int J Mol Sci       Date:  2022-02-24       Impact factor: 5.923

7.  Inflammatory cytokines and mechanical injury induce post-traumatic osteoarthritis-like changes in a human cartilage-bone-synovium microphysiological system.

Authors:  Garima Dwivedi; Lisa Flaman; Begum Alaybeyoglu; André Struglics; Eliot H Frank; Susan Chubinskya; Stephen B Trippel; Vicki Rosen; Murat Cirit; Alan J Grodzinsky
Journal:  Arthritis Res Ther       Date:  2022-08-18       Impact factor: 5.606

8.  Human Mesenchymal Stem Cell-Derived Miniature Joint System for Disease Modeling and Drug Testing.

Authors:  Zhong Li; Zixuan Lin; Silvia Liu; Haruyo Yagi; Xiurui Zhang; Lauren Yocum; Monica Romero-Lopez; Claire Rhee; Meagan J Makarcyzk; Ilhan Yu; Eileen N Li; Madalyn R Fritch; Qi Gao; Kek Boon Goh; Benjamen O'Donnell; Tingjun Hao; Peter G Alexander; Bhushan Mahadik; John P Fisher; Stuart B Goodman; Bruce A Bunnell; Rocky S Tuan; Hang Lin
Journal:  Adv Sci (Weinh)       Date:  2022-04-18       Impact factor: 17.521

9.  Typical response of CD14++CD16- monocyte to knee synovial derived mediators as a key target to overcome the onset and progression of osteoarthritis.

Authors:  Nik Syazana Izyan Saffery; Krishnamurithy Genasan; Chee Ken Chan; Khairul Anwar Ayob; Seow Hui Teo; Mohamed Zubair Mohamed Al-Fayyadh; Iekhsan Othman; Syafiq Asnawi Zainal Abidin; Murali Malliga Raman; Hanumantha Rao Balaji Raghavendran; Tunku Kamarul
Journal:  Front Med (Lausanne)       Date:  2022-08-29
  9 in total

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