IMPORTANCE: There is limited literature on oral statin use and its association with dry eye. BACKGROUND: To analyse the association between dyslipidaemia, use of oral statin drugs, and symptoms of dry eye disease (DED) among older adults. DESIGN: Population-based study. PARTICIPANTS: Participants of the Blue Mountains Eye Study III (BMESIII), a large cohort study in suburban Sydney, aged 60 years or older (mean age = 74, range = 60-97, n = 1680) were analysed. METHODS: Information on DED symptoms and statin use were obtained from an interviewer-administered questionnaire. Serum lipid profiles were determined from fasting blood tests. MAIN OUTCOME MEASURES: The association of various DED symptoms, as well as their number and their severity, with dyslipidaemia and oral statin intake was evaluated. RESULTS: At least one DED symptom was reported in 52% (n = 1029) of the population. Patients with hypercholesterolaemia (>5.5 mmol/L) did not report more DED symptoms than those without hypercholesterolaemia. Neither serum high-density lipoprotein nor low-density lipoprotein levels were associated with any DED symptoms. Patients taking oral statins were more likely to report one or more moderate to severe symptoms of DED (odds ratio: 2.054, 95% confidence interval: 1.281-3.295). CONCLUSIONS AND RELEVANCE: The association between oral statin use and presence of moderate to severe DED symptomatology is a novel finding that deserves further mechanistic and clinical correlation in order to determine its potential, or lack thereof, for the management of dry eye.
IMPORTANCE: There is limited literature on oral statin use and its association with dry eye. BACKGROUND: To analyse the association between dyslipidaemia, use of oral statin drugs, and symptoms of dry eye disease (DED) among older adults. DESIGN: Population-based study. PARTICIPANTS: Participants of the Blue Mountains Eye Study III (BMESIII), a large cohort study in suburban Sydney, aged 60 years or older (mean age = 74, range = 60-97, n = 1680) were analysed. METHODS: Information on DED symptoms and statin use were obtained from an interviewer-administered questionnaire. Serum lipid profiles were determined from fasting blood tests. MAIN OUTCOME MEASURES: The association of various DED symptoms, as well as their number and their severity, with dyslipidaemia and oral statin intake was evaluated. RESULTS: At least one DED symptom was reported in 52% (n = 1029) of the population. Patients with hypercholesterolaemia (>5.5 mmol/L) did not report more DED symptoms than those without hypercholesterolaemia. Neither serum high-density lipoprotein nor low-density lipoprotein levels were associated with any DED symptoms. Patients taking oral statins were more likely to report one or more moderate to severe symptoms of DED (odds ratio: 2.054, 95% confidence interval: 1.281-3.295). CONCLUSIONS AND RELEVANCE: The association between oral statin use and presence of moderate to severe DED symptomatology is a novel finding that deserves further mechanistic and clinical correlation in order to determine its potential, or lack thereof, for the management of dry eye.
Authors: Khalid M Aldaas; Omar M Ismail; Judi Hakim; Eric D Van Buren; Feng-Chang Lin; Joshua S Hardin; Jay J Meyer Journal: Am J Ophthalmol Date: 2020-05-12 Impact factor: 5.258
Authors: Ana F Pereira-da-Mota; María Vivero-Lopez; Ana Topete; Ana Paula Serro; Angel Concheiro; Carmen Alvarez-Lorenzo Journal: Pharmaceutics Date: 2021-04-22 Impact factor: 6.321