Tetsushi Arimura1, Tomoaki Shiba2, Mao Takahashi3, Shun Kumashiro1, Hironori Osamura1, Tadashi Matsumoto1, Ken Sakai4, Yuichi Hori1. 1. Department of Ophthalmology, School of Medicine Toho University, 6-11-1, Omori-Nishi, Ota-ku, Tokyo, 143-8541, Japan. 2. Department of Ophthalmology, School of Medicine Toho University, 6-11-1, Omori-Nishi, Ota-ku, Tokyo, 143-8541, Japan. tomoaki-s@med.toho-u.ac.jp. 3. Cardiovascular Center, Toho University Sakura Medical Center, Chiba, Japan. 4. Department of Nephrology, Toho University School of Medicine, Tokyo, Japan.
Abstract
PURPOSE: To determine the impact that end-stage kidney disease (ESKD) has on ocular microcirculation in the optic nerve head (ONH) and choroid area shown by laser speckle flowgraphy (LSFG). METHODS: We studied 24 consecutive Japanese patients with ESKD who visited the department of Nephrology at our hospital and 55 age- and gender-matched subjects who had undergone polysomnography. The mean blur rates (MBRs) in vessels (MBR-Vessel), in the tissue (MBR-Tissue), throughout the ONH (MBR-All), and throughout the choroid (MBR-Choroid) were analyzed. We divided the MBR-Tissue into four sections (superior, temporal, inferior, and nasal). The results of systemic and ocular parameters were compared between the ESKD patients and control subjects. We performed single and multiple regression analyses to determine the MBR section(s) that correlated most strongly with serum creatinine and the estimated glomerular filtration rate (eGFR) and to identify the independent factors for selected MBR sections in the ESKD patients. RESULTS: All sections of the ONH in the ESKD patients were significantly lower than those in the control subjects. MBR-Choroid was not significantly different between the control and ESKD groups. The single regression analyses revealed that MBR-Tissue had the strongest correlations with creatinine and the eGFR. The multiple regression analyses revealed hematocrit, creatinine, and eGFR as factors independently contributing to the MBR-Tissue. The inferior section of MBR-Tissue was most strongly correlated with creatinine and the eGFR. CONCLUSION: The MBRs in the ONH of the ESKD patients decrease compared with control subjects and the inferior section of MBR-Tissue is correlated with serum creatinine and eGFR.
PURPOSE: To determine the impact that end-stage kidney disease (ESKD) has on ocular microcirculation in the optic nerve head (ONH) and choroid area shown by laser speckle flowgraphy (LSFG). METHODS: We studied 24 consecutive Japanese patients with ESKD who visited the department of Nephrology at our hospital and 55 age- and gender-matched subjects who had undergone polysomnography. The mean blur rates (MBRs) in vessels (MBR-Vessel), in the tissue (MBR-Tissue), throughout the ONH (MBR-All), and throughout the choroid (MBR-Choroid) were analyzed. We divided the MBR-Tissue into four sections (superior, temporal, inferior, and nasal). The results of systemic and ocular parameters were compared between the ESKD patients and control subjects. We performed single and multiple regression analyses to determine the MBR section(s) that correlated most strongly with serum creatinine and the estimated glomerular filtration rate (eGFR) and to identify the independent factors for selected MBR sections in the ESKD patients. RESULTS: All sections of the ONH in the ESKD patients were significantly lower than those in the control subjects. MBR-Choroid was not significantly different between the control and ESKD groups. The single regression analyses revealed that MBR-Tissue had the strongest correlations with creatinine and the eGFR. The multiple regression analyses revealed hematocrit, creatinine, and eGFR as factors independently contributing to the MBR-Tissue. The inferior section of MBR-Tissue was most strongly correlated with creatinine and the eGFR. CONCLUSION: The MBRs in the ONH of the ESKD patients decrease compared with control subjects and the inferior section of MBR-Tissue is correlated with serum creatinine and eGFR.
Authors: Michelle R Tamplin; Kimberly A Broadhurst; Anthony H Vitale; Ryuya Hashimoto; Randy H Kardon; Isabella M Grumbach Journal: Exp Eye Res Date: 2022-01-17 Impact factor: 3.770
Authors: Michelle R Tamplin; Kimberly A Broadhurst; Anthony H Vitale; Ryuya Hashimoto; Randy H Kardon; Isabella M Grumbach Journal: Transl Vis Sci Technol Date: 2021-02-05 Impact factor: 3.283