OBJECTIVE: To perform a comprehensive assessment of long-term quality of life (QOL) and gastrointestinal (GI) function in patients following pancreaticoduodenectomy (PD). SUMMARY OF BACKGROUND DATA: Survival after PD has greatly improved and thus has resulted in a larger population of survivors, yet long-term QOL and GI function after PD is largely unknown. METHODS: Patients were identified from a global online support group. QOL was measured using the Short Form-36, while GI function was assessed using the Gastrointestinal Symptom Rating Scale. QOL and GI function were analyzed across subgroups based on time after PD. QOL was compared with preoperative measurements and with established values of a general healthy population (GHP). Multivariate linear regression was used to identify predictors of QOL. RESULTS: Of the 7605 members of the online support group, 1102 responded to the questionnaire with 927 responders meeting inclusion criteria. Seven hundred seventeen (77.3%) of these responders underwent PD for malignancy. Mean age was 57 ± 12 years and 327 (35%) were male. At the time of survey, patients were 2.0 (0.7, 4.3) years out from surgery, with a maximum 30.7-year response following PD. Emotional and physical domains of QOL improved with time and surpassed preoperative levels between 6 months and 1 year after PD (both P < 0.001). Each GI symptom worsened over time (all P < 0.001). Independent predictors of general QOL in long-term survivors (> 5 years) included total GSRS score [β = -1.70 (-1.91, -1.50)], female sex [β = 3.58 (0.67, 6.46)], and being a cancer survivor [β = 3.93 (0.60, 7.25)]. CONCLUSIONS: Long-term QOL following PD improves over time, however never approaches that of a GHP. GI dysfunction persists in long-term survivors and is an independent predictor of poor QOL. Long-term physical, psychosocial, and GI functional support after PD is encouraged.
OBJECTIVE: To perform a comprehensive assessment of long-term quality of life (QOL) and gastrointestinal (GI) function in patients following pancreaticoduodenectomy (PD). SUMMARY OF BACKGROUND DATA: Survival after PD has greatly improved and thus has resulted in a larger population of survivors, yet long-term QOL and GI function after PD is largely unknown. METHODS:Patients were identified from a global online support group. QOL was measured using the Short Form-36, while GI function was assessed using the Gastrointestinal Symptom Rating Scale. QOL and GI function were analyzed across subgroups based on time after PD. QOL was compared with preoperative measurements and with established values of a general healthy population (GHP). Multivariate linear regression was used to identify predictors of QOL. RESULTS: Of the 7605 members of the online support group, 1102 responded to the questionnaire with 927 responders meeting inclusion criteria. Seven hundred seventeen (77.3%) of these responders underwent PD for malignancy. Mean age was 57 ± 12 years and 327 (35%) were male. At the time of survey, patients were 2.0 (0.7, 4.3) years out from surgery, with a maximum 30.7-year response following PD. Emotional and physical domains of QOL improved with time and surpassed preoperative levels between 6 months and 1 year after PD (both P < 0.001). Each GI symptom worsened over time (all P < 0.001). Independent predictors of general QOL in long-term survivors (> 5 years) included total GSRS score [β = -1.70 (-1.91, -1.50)], female sex [β = 3.58 (0.67, 6.46)], and being a cancer survivor [β = 3.93 (0.60, 7.25)]. CONCLUSIONS: Long-term QOL following PD improves over time, however never approaches that of a GHP. GI dysfunction persists in long-term survivors and is an independent predictor of poor QOL. Long-term physical, psychosocial, and GI functional support after PD is encouraged.
Authors: Lindsay Kennedy Brown; Akbar K Waljee; Peter D R Higgins; Jennifer F Waljee; Arden M Morris Journal: Dis Colon Rectum Date: 2011-12 Impact factor: 4.585
Authors: Jordan M Cloyd; Matthew H G Katz; Laura Prakash; Gauri R Varadhachary; Robert A Wolff; Rachna T Shroff; Milind Javle; David Fogelman; Michael Overman; Christopher H Crane; Eugene J Koay; Prajnan Das; Sunil Krishnan; Bruce D Minsky; Jeffrey H Lee; Manoop S Bhutani; Brian Weston; William Ross; Priya Bhosale; Eric P Tamm; Huamin Wang; Anirban Maitra; Michael P Kim; Thomas A Aloia; Jean-Nicholas Vauthey; Jason B Fleming; James L Abbruzzese; Peter W T Pisters; Douglas B Evans; Jeffrey E Lee Journal: J Gastrointest Surg Date: 2016-10-24 Impact factor: 3.452
Authors: Abhishek D Parmar; Kristin M Sheffield; Gabriela M Vargas; Henry A Pitt; E Molly Kilbane; Bruce L Hall; Taylor S Riall Journal: HPB (Oxford) Date: 2013-07-22 Impact factor: 3.647
Authors: Sven M van Dijk; Hanne D Heerkens; Dorine S J Tseng; Martijn Intven; I Quintus Molenaar; Hjalmar C van Santvoort Journal: HPB (Oxford) Date: 2017-12-15 Impact factor: 3.647
Authors: Mena M Hanna; Rahul Gadde; Casey J Allen; Jonathan P Meizoso; Danny Sleeman; Alan S Livingstone; Nipun Merchant; Danny Yakoub Journal: J Surg Res Date: 2016-01-06 Impact factor: 2.192
Authors: Steven Gittelman; Victor Lange; Carol A Gotway Crawford; Catherine A Okoro; Eugene Lieb; Satvinder S Dhingra; Elaine Trimarchi Journal: J Med Internet Res Date: 2015-04-20 Impact factor: 5.428
Authors: Casey J Allen; Nikhil G Thaker; Laura Prakash; Brittany C Kruse; Thomas W Feeley; Robert S Kaplan; Ryan Huey; Steven J Frank; Thomas A Aloia; Vijaya Gottumukkala; Matthew H G Katz Journal: Ann Surg Date: 2021-01-01 Impact factor: 13.787
Authors: Michael R Driedger; Carlos A Puig; Cornelius A Thiels; John R Bergquist; Daniel S Ubl; Elizabeth B Habermann; Travis E Grotz; Rory L Smoot; David M Nagorney; Sean P Cleary; Michael L Kendrick; Mark J Truty Journal: BMC Surg Date: 2020-07-27 Impact factor: 2.102
Authors: Kasper A Overbeek; Djuna L Cahen; Anne Kamps; Ingrid C A W Konings; Femme Harinck; Marianne A Kuenen; Bas Groot Koerkamp; Marc G Besselink; Casper H van Eijck; Anja Wagner; Margreet G E Ausems; Manon van der Vlugt; Paul Fockens; Frank P Vleggaar; Jan-Werner Poley; Jeanin E van Hooft; Eveline M A Bleiker; Marco J Bruno Journal: Fam Cancer Date: 2020-07 Impact factor: 2.375