Literature DB >> 30198761

Pathways from racial discrimination to cortisol/DHEA imbalance: protective role of religious involvement.

Daniel B Lee1, Melissa K Peckins2, Alison L Miller3, Meredith O Hope3, Enrique W Neblett4, Shervin Assari3, Jaime Muñoz-Velázquez2, Marc A Zimmerman3.   

Abstract

Objective: Racial discrimination (RD) is hypothesized to dysregulate the production of stress reactive hormones among African Americans. Psychological processes that may mediate the association between RD and such dysregulation (e.g. cortisol/DHEA ratio) are not well articulated. Organizational religious involvement (ORI) has been discussed as a psychological protective factor within the context of RD, but our understanding of ORI as a physiological protective factor remains limited. We evaluated whether RD was directly and indirectly (through depressive symptoms) associated with an imbalance of cortisol and DHEA hormones, and whether ORI buffered these direct and/or indirect pathways.Design: Data were drawn from the Flint Adolescent Study, an ongoing interview study of youth that began in 1994. Participants were 188 African American emerging adults (47.3% Female, ages 20-22). We used mediation and moderated-mediation analyses, as outlined by Hayes [2012. PROCESS SPSS Macro. [Computer Software and Manual]. http://www.afhayes.com/public/process.pdf], to evaluate the study aims.
Results: We found that depressive symptoms mediated the association between RD and the cortisol/DHEA ratio. We also found that depressive symptoms mediated the association between RD and the cortisol/DHEA ratio for individuals reporting low and moderate levels of ORI, but not at high levels.Conclusions: Our findings support the socio-psychobiological model of racism and health [Chae et al. 2011. "Conceptualizing Racial Disparities in Health: Advancement of a Socio-Psychobiological Approach." Du Bois Review: Social Science Research on Race 8 (1): 63-77. doi:10.1017/S1742058X11000166] and suggest that the psychological toll of RD can confer physiological consequences. Moreover, ORI may disrupt pathways from RD to cortisol/DHEA ratio by buffering the psychological toll of RD.

Entities:  

Keywords:  Racial discrimination; neuroendocrine response; religion; resilience

Mesh:

Substances:

Year:  2018        PMID: 30198761      PMCID: PMC6409100          DOI: 10.1080/13557858.2018.1520815

Source DB:  PubMed          Journal:  Ethn Health        ISSN: 1355-7858            Impact factor:   2.772


  44 in total

1.  Dehydroepiandrosterone sulfate (DHEAS) counteracts decremental effects of corticosterone on dentate gyrus LTP. Implications for depression.

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2.  Forgiveness by God, Forgiveness of Others, and Psychological Well-Being in Late Life.

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3.  The link between discrimination and telomere length in African American adults.

Authors:  Daniel B Lee; Eric S Kim; Enrique W Neblett
Journal:  Health Psychol       Date:  2017-05       Impact factor: 4.267

Review 4.  Cortisol and DHEA in development and psychopathology.

Authors:  Hayley S Kamin; Darlene A Kertes
Journal:  Horm Behav       Date:  2016-12-12       Impact factor: 3.587

5.  Clinical correlates of DHEA associated with post-traumatic stress disorder.

Authors:  R Yehuda; S R Brand; J A Golier; R-K Yang
Journal:  Acta Psychiatr Scand       Date:  2006-09       Impact factor: 6.392

6.  Depressive symptoms are associated with blunted cortisol stress responses in very low-income women.

Authors:  Heather M Burke; Lia C Fernald; Paul J Gertler; Nancy E Adler
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7.  Blunted cortisol response to awakening in mild to moderate depression: regulatory influences of sleep patterns and social contacts.

Authors:  Cinnamon Stetler; Gregory E Miller
Journal:  J Abnorm Psychol       Date:  2005-11

8.  DHEA-S levels and depressive symptoms in a cohort of African American and Caucasian women in the late reproductive years.

Authors:  M F Morrison; T Ten Have; E W Freeman; M D Sammel; J A Grisso
Journal:  Biol Psychiatry       Date:  2001-11-01       Impact factor: 13.382

9.  Elevated salivary dehydroepiandrosterone-sulfate but normal cortisol levels in medicated depressed patients: preliminary findings.

Authors:  Johanna Assies; Ieke Visser; Nancy A Nicolson; Teunis A Eggelte; Elisabeth M Wekking; Jochanan Huyser; Ritsaert Lieverse; Aart H Schene
Journal:  Psychiatry Res       Date:  2004-09-30       Impact factor: 3.222

10.  Prognostic value of dehydroepiandrosterone-sulfate and other parameters of adrenal function in acute ischemic stroke.

Authors:  Claudine A Blum; Cornelia Mueller; Philipp Schuetz; Felix Fluri; Michael Trummler; Beat Mueller; Mira Katan; Mirjam Christ-Crain
Journal:  PLoS One       Date:  2013-05-01       Impact factor: 3.240

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  6 in total

Review 1.  Sex Differences in the Impact of Racial Discrimination on Mental Health Among Black Americans.

Authors:  Briana N Brownlow; Effua E Sosoo; Risa N Long; Lori S Hoggard; Tanisha I Burford; LaBarron K Hill
Journal:  Curr Psychiatry Rep       Date:  2019-11-04       Impact factor: 5.285

2.  Educating Health Professions Educators to Address the "isms".

Authors:  Kennita R Carter; Sandra Crewe; Mildred C Joyner; Angelo McClain; Carl J Sheperis; Stephanie Townsell
Journal:  NAM Perspect       Date:  2020-08-31

Review 3.  Integrating genetic and social factors to understand health disparities in lupus.

Authors:  Paula S Ramos
Journal:  Curr Opin Rheumatol       Date:  2021-11-01       Impact factor: 4.941

4.  Black Caribbean Emerging Adults: A Systematic Review of Religion and Health.

Authors:  Meredith O Hope; Tamara Taggart; Kayoll V Galbraith-Gyan; Kate Nyhan
Journal:  J Relig Health       Date:  2020-02

5.  Associations between multiple indicators of discrimination and allostatic load among middle-aged adults.

Authors:  Jourdyn A Lawrence; Ichiro Kawachi; Kellee White; Mary T Bassett; David R Williams
Journal:  Soc Sci Med       Date:  2022-03-04       Impact factor: 5.379

6.  Psychosocial stress and neuroendocrine biomarker concentrations among women living with or without HIV.

Authors:  Matthew E Levy; Ansley Waters; Sabyasachi Sen; Amanda D Castel; Michael Plankey; Sherry Molock; Federico Asch; Lakshmi Goparaju; Seble Kassaye
Journal:  PLoS One       Date:  2021-12-23       Impact factor: 3.240

  6 in total

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