Literature DB >> 3019772

Protein kinase C regulates leukotriene B4 receptors in human neutrophils.

J T O'Flaherty, J F Redman, D P Jacobson.   

Abstract

Three protein kinase C (PKC) activators, viz. phorbol myristate acetate, mezerein, and rac-1-O-myristoyl-2-acetylglycerol, inhibited human neutrophil binding of [3H] leukotriene B4 (LTB4) by reducing the number of high-affinity receptors available to the arachidonic acid metabolite. The inhibitory effect occurred in whole cells and cytoplasts but not in isolated membranes; it appeared to involve the activation of PKC rather than direct competition for binding sites. PKC may govern cellular responsiveness by regulating the receptor-linked bioactions of endogenous mediators like LTB4.

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Year:  1986        PMID： 3019772     DOI： 10.1016/0014-5793(86)80996-6

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  6 in total

1.  Studies on the uptake, binding and metabolism of leukotriene B4 by human neutrophils.

Authors:  J Brom; W König
Journal:  Immunology       Date:  1989-12       Impact factor: 7.397

Review 2.  Regulation of protein kinase C activity by various lipids.

Authors:  A A Farooqui; T Farooqui; A J Yates; L A Horrocks
Journal:  Neurochem Res       Date:  1988-06       Impact factor: 3.996

3.  Stimulation of protein kinase C redistribution and inhibition of leukotriene B4-induced inositol 1,4,5-trisphosphate generation in human neutrophils by lipoxin A4.

Authors:  K O Chung-a-on; O Soyombo; B W Spur; T H Lee
Journal:  Br J Pharmacol       Date:  1996-03       Impact factor: 8.739

4.  Metabolism of leukotriene B4 by activated human polymorphonuclear granulocytes.

Authors:  J Brom; W Schönfeld; W König
Journal:  Immunology       Date:  1988-07       Impact factor: 7.397

5.  Phorbol 12-myristate 13-acetate inhibits binding of leukotriene B4 and platelet-activating factor and the responses they induce in neutrophils: site of action.

Authors:  M Yamazaki; J Gomez-Cambronero; M Durstin; T F Molski; E L Becker; R I Sha'afi
Journal:  Proc Natl Acad Sci U S A       Date:  1989-08       Impact factor: 11.205

6.  Eicosapentaenoic acid modulates neutrophil leukotriene B4 receptor expression in cystic fibrosis.

Authors:  R H Lawrence; T C Sorrell
Journal:  Clin Exp Immunol       Date:  1994-10       Impact factor: 4.330
  6 in total

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