Literature DB >> 3019757

Effects of 18-hydroxydeoxycorticosterone on central nervous system excitability.

B Dubrovsky, J Illes, M K Birmingham.   

Abstract

The effects of 18-hydroxydeoxycorticosterone (18-OH-DOC) on central nervous system excitability were studied in adrenalectomized rats. Sixty-four evoked potentials (EP) recorded from the pontine reticular formation were averaged before and after the injection of vehicle and hormone. 750 micrograms of 18-OH-DOC dissolved in 0.5 ml of a 4:1 saline Cremophor-EL solution were injected i.v. A decrease of 55.7 +/- 6.1% in the amplitude of the EPs was observed with the hormone 16.3 min +/- 2.7 (SE) after injection. Amplitude values returned to baseline levels 38 min +/- 6.8 (SE) after injection. The secretion of 18-OH-DOC is greatly increased by ACTH and might modulate central nervous system function.

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Year:  1986        PMID： 3019757     DOI： 10.1007/bf01940717

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  5 in total

1.  Production of steroids in vivo by regenerated adrenal glands of hypertensive and normotensive rats.

Authors:  M K Birmingham; A F De Nicola; J T Oliver; H Traikov; M L Birmingham; M Holzbauer; U Godden; D F Sharman
Journal:  Endocrinology       Date:  1973-08       Impact factor: 4.736

Review 2.  Actions of estrogens and progestins on nerve cells.

Authors:  D W Pfaff; B S McEwen
Journal:  Science       Date:  1983-02-18       Impact factor: 47.728

3.  Effects of deoxycorticosterone and its ring A-reduced derivatives on the nervous system.

Authors:  B Dubrovsky; D Williams; I Kraulis
Journal:  Exp Neurol       Date:  1982-12       Impact factor: 5.330

4.  Distribution, metabolism and biological activity of deoxycorticosterone in the central nervous system.

Authors:  I Kraulis; G Foldes; H Traikov; B Dubrovsky
Journal:  Brain Res       Date:  1975-04-25       Impact factor: 3.252

5.  Localization of aldosterone and corticosterone in the central nervous system, assessed by quantitative autoradiography.

Authors:  M K Birmingham; M Sar; W E Stumpf
Journal:  Neurochem Res       Date:  1984-03       Impact factor: 3.996
  5 in total
  1 in total

1.  Effects of adrenocortical steroids on long-term potentiation in the limbic system: basic mechanisms and behavioral consequences.

Authors:  B Dubrovsky; K Gijsbers; D Filipini; M K Birmingham
Journal:  Cell Mol Neurobiol       Date:  1993-08       Impact factor: 5.046
  1 in total

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