Bárbara Matos1,2, John Howl3, Rita Ferreira1, Margarida Fardilha4. 1. QOPNA, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal. 2. Signal Transduction Laboratory, iBiMED, Department of Medical Sciences, University of Aveiro, 3810-193, Aveiro, Portugal. 3. Molecular Pharmacology Group, Research Institute in Healthcare Science, University of Wolverhampton, Wolverhampton, WV1 1LY, UK. 4. Signal Transduction Laboratory, iBiMED, Department of Medical Sciences, University of Aveiro, 3810-193, Aveiro, Portugal. mfardilha@ua.pt.
Abstract
PURPOSE: The impact of exercise training on testicular function is relatively ill-defined. To gain new insights into this important topic, published data, deriving from both humans and animal studies, were critically analyzed. RESULTS AND CONCLUSIONS: The effects of exercise on the hypothalamus-pituitary-gonadal axis, influenced by the type, intensity and duration of the exercise program, can be evaluated in terms of total and free testosterone and/or luteinizing hormone and follicle-stimulating hormone serum levels and sperm parameters. High-intensity exercise promotes a common decrease in these parameters, and therefore, negatively impacts upon testicular function. However, published data for moderate-intensity exercise training are inconsistent. Conversely, there is consistent evidence to support the benefits of exercise training to prevent and/or counteract the impairment of testis function caused by aging, obesity and doxorubicin treatment. This positive effect is likely the consequence of decreased oxidative stress and inflammatory status. In the future, it will be important to clarify the molecular mechanisms which explain these reported discrepancies and to establish guidelines for an active lifestyle to promote healthy testicular function.
PURPOSE: The impact of exercise training on testicular function is relatively ill-defined. To gain new insights into this important topic, published data, deriving from both humans and animal studies, were critically analyzed. RESULTS AND CONCLUSIONS: The effects of exercise on the hypothalamus-pituitary-gonadal axis, influenced by the type, intensity and duration of the exercise program, can be evaluated in terms of total and free testosterone and/or luteinizing hormone and follicle-stimulating hormone serum levels and sperm parameters. High-intensity exercise promotes a common decrease in these parameters, and therefore, negatively impacts upon testicular function. However, published data for moderate-intensity exercise training are inconsistent. Conversely, there is consistent evidence to support the benefits of exercise training to prevent and/or counteract the impairment of testis function caused by aging, obesity and doxorubicin treatment. This positive effect is likely the consequence of decreased oxidative stress and inflammatory status. In the future, it will be important to clarify the molecular mechanisms which explain these reported discrepancies and to establish guidelines for an active lifestyle to promote healthy testicular function.
Authors: Alessandra Santillo; Antonia Giacco; Sara Falvo; Federica Di Giacomo Russo; Rosalba Senese; Maria Maddalena Di Fiore; Gabriella Chieffi Baccari; Antonia Lanni; Pieter de Lange Journal: Front Endocrinol (Lausanne) Date: 2020-05-13 Impact factor: 5.555
Authors: Joana V Silva; Joana Santiago; Bárbara Matos; Magda C Henriques; Daniela Patrício; Ana D Martins; José A Duarte; Rita Ferreira; Marco G Alves; Paula Oliveira; Pedro F Oliveira; Margarida Fardilha Journal: Int J Mol Sci Date: 2022-10-01 Impact factor: 6.208
Authors: Adi Lukas Kurniawan; Chien-Yeh Hsu; Jane C-J Chao; Li-Yin Lin; Rathi Paramastri; Hsiu-An Lee; Nan-Chen Hsieh; Shu-Fang Vivienne Wu Journal: Int J Environ Res Public Health Date: 2021-05-05 Impact factor: 3.390
Authors: Marcin Grandys; Joanna Majerczak; Justyna Zapart-Bukowska; Krzysztof Duda; Jan K Kulpa; Jerzy A Zoladz Journal: Front Endocrinol (Lausanne) Date: 2021-09-09 Impact factor: 5.555