Lorenzo Gaetani1, Luca Prosperini2,3, Andrea Mancini1, Paolo Eusebi1, Maria Chiara Cerri1, Carlo Pozzilli2, Paolo Calabresi1,4, Paola Sarchielli1, Massimiliano Di Filippo5. 1. Clinica Neurologica, Dipartimento di Medicina, Ospedale S. Maria della Misericordia, Università degli Studi di Perugia, 06156, Perugia, Italy. 2. Department of Neurology and Psychiatry, Sapienza University, Rome, Italy. 3. Department of Neurosciences, S. Camillo-Forlanini Hospital, Rome, Italy. 4. IRCCS Fondazione Santa Lucia, Rome, Italy. 5. Clinica Neurologica, Dipartimento di Medicina, Ospedale S. Maria della Misericordia, Università degli Studi di Perugia, 06156, Perugia, Italy. massimiliano.difilippo@unipg.it.
Abstract
OBJECTIVES: To investigate the impact of the 2017 revisions of McDonald criteria on the diagnosis of multiple sclerosis (MS) in a cohort of patients with clinically isolated syndrome (CIS) and dissemination in space (DIS) of demyelinating lesions. METHODS: We retrospectively analyzed 137 patients with CIS + DIS from two Italian MS centers. RESULTS: Application of the 2017 revisions of McDonald criteria in our cohort led to a diagnosis of MS in 82.5% of the patients who could have not been diagnosed with MS according to the previous criteria at the time of the first demyelinating event. After a follow-up of 3.8 ± 2.9 years, 85.8% of these patients eventually satisfied also the previous (2010) criteria. CONCLUSIONS: Application of the 2017 revisions of McDonald criteria results in an earlier diagnosis of MS in a large percentage of CIS patients destined to convert to MS.
OBJECTIVES: To investigate the impact of the 2017 revisions of McDonald criteria on the diagnosis of multiple sclerosis (MS) in a cohort of patients with clinically isolated syndrome (CIS) and dissemination in space (DIS) of demyelinating lesions. METHODS: We retrospectively analyzed 137 patients with CIS + DIS from two Italian MS centers. RESULTS: Application of the 2017 revisions of McDonald criteria in our cohort led to a diagnosis of MS in 82.5% of the patients who could have not been diagnosed with MS according to the previous criteria at the time of the first demyelinating event. After a follow-up of 3.8 ± 2.9 years, 85.8% of these patients eventually satisfied also the previous (2010) criteria. CONCLUSIONS: Application of the 2017 revisions of McDonald criteria results in an earlier diagnosis of MS in a large percentage of CIS patients destined to convert to MS.
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