Richard F Dunne1, Breton Roussel2, Eva Culakova3, Chintan Pandya4, Fergal J Fleming4, Bradley Hensley4, Allison M Magnuson3, Kah Poh Loh4, Maxence Gilles4, Erika Ramsdale3, Ronald J Maggiore4, Aminah Jatoi5, Karen M Mustian3, William Dale6, Supriya G Mohile3. 1. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, United States; University of Rochester NCI Community Oncology Research Program (UR NCORP), Rochester, NY, United States. Electronic address: richard_dunne@urmc.rochester.edu. 2. Department of Medicine, Brown University, Providence, RI, United States. 3. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, United States; University of Rochester NCI Community Oncology Research Program (UR NCORP), Rochester, NY, United States. 4. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, United States. 5. Mayo Clinic, Department of Oncology, Rochester, MN, United States. 6. City of Hope, Department of Supportive Care Medicine, Duarte, CA, United States.
Abstract
OBJECTIVES: Cancer cachexia, characterized by weight loss and sarcopenia, leads to a decline in physical function and is associated with poorer survival. Cancer cachexia remains poorly described in older adults with cancer. This study aims to characterize cancer cachexia in older adults by assessing its prevalence utilizing standard definitions and evaluating associations with components of the geriatric assessment (GA) and survival. MATERIALS AND METHODS: Patients with cancer older than 65 years of age who underwent a GA and had baseline CT imaging were eligible in this cross-sectional study. Cancer cachexia was defined by the international consensus definition reported in 2011. Sarcopenia was measured using cross-sectional imaging and utilizing sex-specific cut-offs. Associations between cachexia, sarcopenia, and weight loss with survival and GA domains were explored. RESULTS: Mean age of 100 subjects was 79.9 years (66-95) and 65% met criteria for cancer cachexia. Cachexia was associated with impairment in instrumental activities of daily living (IADL) (p = .017); no significant association was found between sarcopenia or weight loss and IADL impairment. Cachexia was significantly associated with poorer survival (median 1.0 vs 2.1 years, p = .011). CONCLUSIONS: Cancer cachexia as defined by the international consensus definition is prevalent in older adults with cancer and is associated with functional impairment and decreased survival. Larger prospective studies are needed to further describe cancer cachexia in this population.
OBJECTIVES:Cancer cachexia, characterized by weight loss and sarcopenia, leads to a decline in physical function and is associated with poorer survival. Cancer cachexia remains poorly described in older adults with cancer. This study aims to characterize cancer cachexia in older adults by assessing its prevalence utilizing standard definitions and evaluating associations with components of the geriatric assessment (GA) and survival. MATERIALS AND METHODS:Patients with cancer older than 65 years of age who underwent a GA and had baseline CT imaging were eligible in this cross-sectional study. Cancer cachexia was defined by the international consensus definition reported in 2011. Sarcopenia was measured using cross-sectional imaging and utilizing sex-specific cut-offs. Associations between cachexia, sarcopenia, and weight loss with survival and GA domains were explored. RESULTS: Mean age of 100 subjects was 79.9 years (66-95) and 65% met criteria for cancer cachexia. Cachexia was associated with impairment in instrumental activities of daily living (IADL) (p = .017); no significant association was found between sarcopenia or weight loss and IADL impairment. Cachexia was significantly associated with poorer survival (median 1.0 vs 2.1 years, p = .011). CONCLUSIONS:Cancer cachexia as defined by the international consensus definition is prevalent in older adults with cancer and is associated with functional impairment and decreased survival. Larger prospective studies are needed to further describe cancer cachexia in this population.
Authors: Matthew R Smith; Fred Saad; Blair Egerdie; Paul R Sieber; Teuvo L J Tammela; Chunlei Ke; Benjamin Z Leder; Carsten Goessl Journal: J Clin Oncol Date: 2012-05-29 Impact factor: 44.544
Authors: Richard F Dunne; Karen M Mustian; Jose M Garcia; William Dale; Reid Hayward; Breton Roussel; Mary M Buschmann; Bette J Caan; Calvin L Cole; Fergal J Fleming; Joe V Chakkalakal; David C Linehan; Aram F Hezel; Supriya G Mohile Journal: Curr Opin Support Palliat Care Date: 2017-12 Impact factor: 2.302
Authors: D Blum; G B Stene; T S Solheim; P Fayers; M J Hjermstad; V E Baracos; K Fearon; F Strasser; S Kaasa Journal: Ann Oncol Date: 2014-02-20 Impact factor: 32.976
Authors: Kenneth Fearon; Florian Strasser; Stefan D Anker; Ingvar Bosaeus; Eduardo Bruera; Robin L Fainsinger; Aminah Jatoi; Charles Loprinzi; Neil MacDonald; Giovanni Mantovani; Mellar Davis; Maurizio Muscaritoli; Faith Ottery; Lukas Radbruch; Paula Ravasco; Declan Walsh; Andrew Wilcock; Stein Kaasa; Vickie E Baracos Journal: Lancet Oncol Date: 2011-02-04 Impact factor: 41.316
Authors: Alfonso J Cruz-Jentoft; Jean Pierre Baeyens; Jürgen M Bauer; Yves Boirie; Tommy Cederholm; Francesco Landi; Finbarr C Martin; Jean-Pierre Michel; Yves Rolland; Stéphane M Schneider; Eva Topinková; Maurits Vandewoude; Mauro Zamboni Journal: Age Ageing Date: 2010-04-13 Impact factor: 10.668
Authors: Carla M M Prado; Jessica R Lieffers; Linda J McCargar; Tony Reiman; Michael B Sawyer; Lisa Martin; Vickie E Baracos Journal: Lancet Oncol Date: 2008-06-06 Impact factor: 41.316
Authors: James R Broughman; Grant R Williams; Allison M Deal; Hyeon Yu; Kirsten A Nyrop; Shani M Alston; Brittaney-Belle Gordon; Hanna K Sanoff; Hyman B Muss Journal: J Geriatr Oncol Date: 2015-09-11 Impact factor: 3.599
Authors: Marina Mourtzakis; Carla M M Prado; Jessica R Lieffers; Tony Reiman; Linda J McCargar; Vickie E Baracos Journal: Appl Physiol Nutr Metab Date: 2008-10 Impact factor: 2.665
Authors: Thuy T Koll; Allison Magnuson; William Dale; Mark A LaBarge; Corinne R Leach; Supriya Mohile; Hyman Muss; Margaret Sedenquist; Heidi D Klepin Journal: J Geriatr Oncol Date: 2019-09-16 Impact factor: 3.599
Authors: Richard F Dunne; Kah Poh Loh; Grant R Williams; Aminah Jatoi; Karen M Mustian; Supriya G Mohile Journal: Cancers (Basel) Date: 2019-11-25 Impact factor: 6.639