| Literature DB >> 3019492 |
T Sugimoto, M Nakada, M Fukase, Y Imai, Y Kinoshita, T Fujita.
Abstract
L-ascorbic acid at physiological concentrations (10 micrograms/ml) increased alkaline phosphatase activity in the osteoblastlike rat osteosarcoma cell line, UMR-106. The increase was dose-dependent and detectable at 6 hours after the addition of 100 micrograms/ml ascorbic acid to the medium. Treatment of the cells with 100 micrograms/ml ascorbic acid potentiated the response of cAMP to both PTH and PGE1, while cell growth was inhibited. Furthermore, the number of colonies formed by the cells grown in the soft agar was significantly reduced by increasing concentrations of ascorbic acid. These results indicate that ascorbic acid might play some role in the differentiation of osteoblasts.Entities:
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Year: 1986 PMID： 3019492 DOI： 10.1007/bf02555114
Source DB: PubMed Journal: Calcif Tissue Int ISSN： 0171-967X Impact factor: 4.333