Mariela Bernabe-García1, Maricela Rodríguez-Cruz2, Salvador Atilano2, Oriana Del Rocío Cruz-Guzmán2, Tomás Almeida-Becerril2, Philip C Calder3,4, Julia González2. 1. Unidad de Investigación Médica en Nutrición, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Avenida Cuauhtémoc No. 330, Col. Doctores, Delegación Cuauhtémoc, 06725, Ciudad de México, México. 2. Laboratorio de Nutrición Molecular, Unidad de Investigación Médica en Nutrición, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México. 3. Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK. 4. NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, UK.
Abstract
INTRODUCTION: In Duchenne muscular dystrophy (DMD) muscle is replaced by adipose tissue. The role of dietary intake (DI) in DMD has not been evaluated. In this study we examined body composition, body mass index (BMI), and adequacy of DI in patients with DMD and evaluated the influence of DI on body composition. METHODS: Patients (n = 101; age 3-18 years; BMI 11.8-29.5 kg/m2 ) completed a dietary recall to determine DI and then underwent dual-energy X-ray absorptiometry to determine body composition. RESULTS: Preschool-age and school-age boys with DMD had high total energy intake. Protein intake per kilogram exceeded recommendations. As age increased, the percentage of boys with abnormal BMI and fat mass increased, while lean mass decreased. Dietary intake did not predict body fat or lean mass. DISCUSSION: Age-dependent changes in BD in boys with DMD may be due to endogenous metabolic factors related to the underlying disease process and to disease-related mobility impairments. Muscle Nerve 59:295-302, 2019.
INTRODUCTION: In Duchenne muscular dystrophy (DMD) muscle is replaced by adipose tissue. The role of dietary intake (DI) in DMD has not been evaluated. In this study we examined body composition, body mass index (BMI), and adequacy of DI in patients with DMD and evaluated the influence of DI on body composition. METHODS:Patients (n = 101; age 3-18 years; BMI 11.8-29.5 kg/m2 ) completed a dietary recall to determine DI and then underwent dual-energy X-ray absorptiometry to determine body composition. RESULTS: Preschool-age and school-age boys with DMD had high total energy intake. Protein intake per kilogram exceeded recommendations. As age increased, the percentage of boys with abnormal BMI and fat mass increased, while lean mass decreased. Dietary intake did not predict body fat or lean mass. DISCUSSION: Age-dependent changes in BD in boys with DMD may be due to endogenous metabolic factors related to the underlying disease process and to disease-related mobility impairments. Muscle Nerve 59:295-302, 2019.
Authors: Saskia L S Houwen-van Opstal; Lotte Heutinck; Merel Jansen; Yvonne D Krom; Edith H C Cup; Jos G M Hendriksen; Michel A A P Willemsen; Jan J G M Verschuuren; Erik H Niks; Imelda J M de Groot Journal: Muscle Nerve Date: 2021-09-09 Impact factor: 3.852
Authors: Ingrid E C Verhaart; Davy van de Vijver; Joke W Boertje-van der Meulen; Kayleigh Putker; Kevin Adamzek; Annemieke Aartsma-Rus; Maaike van Putten Journal: PLoS One Date: 2019-04-24 Impact factor: 3.240
Authors: Cheryl A Hawkes; Christopher J Heath; Matthew M Sharp; Dariusz C Górecki; Roxana O Carare Journal: Acta Neuropathol Commun Date: 2022-08-31 Impact factor: 7.578
Authors: Evellyn C Grilo; Thais A Cunha; Ádila Danielly S Costa; Bárbara G M Araújo; Márcia Marília G D Lopes; Bruna L L Maciel; Camila X Alves; Karina M Vermeulen-Serpa; Mário Emílio T Dourado-Júnior; Lucia Leite-Lais; José Brandão-Neto; Sancha Helena L Vale Journal: PLoS One Date: 2020-11-20 Impact factor: 3.240