Daifeng Dong1, Qingsen Ming2, Xue Zhong1, Weidan Pu1, Xiaocui Zhang1, Yali Jiang1, Yidian Gao1, Xiaoqiang Sun1, Xiang Wang1, Shuqiao Yao3. 1. Medical Psychological Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China; Medical Psychological Institute of Central South University, Changsha, Hunan, PR China; China National Clinical Research Center on Mental Disorders (Xiangya), Changsha, Hunan, PR China. 2. Dpartment of Psychiatry, The First Affiliated Hospital of Sochoow University, Suzhou, Jiangsu, PR China. 3. Medical Psychological Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China; Medical Psychological Institute of Central South University, Changsha, Hunan, PR China; China National Clinical Research Center on Mental Disorders (Xiangya), Changsha, Hunan, PR China. Electronic address: shuqiaoyao@csu.edu.cn.
Abstract
BACKGROUND: It has been proposed that state-independent, or trait, neurobiological alterations across illness phases may contribute to the high recurrence of major depressive disorder (MDD). Although intrinsic brain network abnormalities have been implicated consistently in MDD neuropathology, MDD state-independent and -dependent resting-state network alterations have not been clearly studied. METHODS: Resting-state functional magnetic resonance imaging (fMRI) data were collected from 57 medication-naive first-episode current MDD patients, 35 remitted MDD patients, and 66 healthy controls (HCs). Independent component analysis (ICA) was used to extract subnetworks of the default mode network (DMN), central executive network (CEN), and salience network (SN). RESULTS: Relative to HCs, the current MDD and remitted MDD groups had decreased intra-intrinsic functional connectivity (iFC) in the dorsal lateral prefrontal cortex (dlPFC) of the left CEN, increased inter-FC between the SN and right CEN (rCEN), and decreased inter-FC between the anterior DMN (aDMN) and rCEN. The altered intra-iFC in the left CEN were correlated negatively with the depressive level in the remitted MDD. CONCLUSIONS: Hypoactivity of the dlPFC in the left CEN, increased inter-FC between the SN and rCEN, and decreased inter-FC between the aDMN and rCEN may reflect state-independent biomarkers of MDD.
BACKGROUND: It has been proposed that state-independent, or trait, neurobiological alterations across illness phases may contribute to the high recurrence of major depressive disorder (MDD). Although intrinsic brain network abnormalities have been implicated consistently in MDD neuropathology, MDD state-independent and -dependent resting-state network alterations have not been clearly studied. METHODS: Resting-state functional magnetic resonance imaging (fMRI) data were collected from 57 medication-naive first-episode current MDDpatients, 35 remitted MDDpatients, and 66 healthy controls (HCs). Independent component analysis (ICA) was used to extract subnetworks of the default mode network (DMN), central executive network (CEN), and salience network (SN). RESULTS: Relative to HCs, the current MDD and remitted MDD groups had decreased intra-intrinsic functional connectivity (iFC) in the dorsal lateral prefrontal cortex (dlPFC) of the left CEN, increased inter-FC between the SN and right CEN (rCEN), and decreased inter-FC between the anterior DMN (aDMN) and rCEN. The altered intra-iFC in the left CEN were correlated negatively with the depressive level in the remitted MDD. CONCLUSIONS: Hypoactivity of the dlPFC in the left CEN, increased inter-FC between the SN and rCEN, and decreased inter-FC between the aDMN and rCEN may reflect state-independent biomarkers of MDD.